Pharmacokinetics and Biodistribution of Eriocitrin in Rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUSDA-
Autor(es): dc.creatorFerreira, Paula S. [UNESP]-
Autor(es): dc.creatorManthey, John A.-
Autor(es): dc.creatorNery, Marina S. [UNESP]-
Autor(es): dc.creatorCesar, Thais B. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:44Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jafc.0c04553-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207274-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207274-
Descrição: dc.descriptionEriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1-
Descrição: dc.descriptionU.S. Horticultural Research Laboratory Agricultural Research Service USDA, 2001 South Rock Road-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1-
Formato: dc.format1796-1805-
Idioma: dc.languageen-
Relação: dc.relationJournal of Agricultural and Food Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiodistribution-
Palavras-chave: dc.subjecteriocitrin-
Palavras-chave: dc.subjectidentification-
Palavras-chave: dc.subjectmetabolites-
Palavras-chave: dc.subjectpharmacokinetics-
Título: dc.titlePharmacokinetics and Biodistribution of Eriocitrin in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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