Dynamic sex chromosome expression in Drosophila male germ cells

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Autor(es): dc.contributorNational Institutes of Health-
Autor(es): dc.contributorJohns Hopkins University School of Medicine-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUppsala University-
Autor(es): dc.contributorNorthwestern University-
Autor(es): dc.creatorMahadevaraju, Sharvani-
Autor(es): dc.creatorFear, Justin M.-
Autor(es): dc.creatorAkeju, Miriam-
Autor(es): dc.creatorGalletta, Brian J.-
Autor(es): dc.creatorPinheiro, Mara M. L. S.-
Autor(es): dc.creatorAvelino, Camila C.-
Autor(es): dc.creatorCabral-de-Mello, Diogo C. [UNESP]-
Autor(es): dc.creatorConlon, Katie-
Autor(es): dc.creatorDell’Orso, Stafania-
Autor(es): dc.creatorDemere, Zelalem-
Autor(es): dc.creatorMansuria, Kush-
Autor(es): dc.creatorMendonça, Carolina A.-
Autor(es): dc.creatorPalacios-Gimenez, Octavio M.-
Autor(es): dc.creatorRoss, Eli-
Autor(es): dc.creatorSavery, Max-
Autor(es): dc.creatorYu, Kevin-
Autor(es): dc.creatorSmith, Harold E.-
Autor(es): dc.creatorSartorelli, Vittorio-
Autor(es): dc.creatorYang, Haiwang-
Autor(es): dc.creatorRusan, Nasser M.-
Autor(es): dc.creatorVibranovski, Maria D.-
Autor(es): dc.creatorMatunis, Erika-
Autor(es): dc.creatorOliver, Brian-
Data de aceite: dc.date.accessioned2022-02-22T00:49:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-021-20897-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207265-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207265-
Descrição: dc.descriptionGiven their copy number differences and unique modes of inheritance, the evolved gene content and expression of sex chromosomes is unusual. In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense mechanism against insertions into unpaired chromatin. In addition to current sex chromosomes, Drosophila has a small gene-poor X-chromosome relic (4th) that re-acquired autosomal status. Here we use single cell RNA-Seq on fly larvae to demonstrate that the single X and pair of 4th chromosomes are specifically inactivated in primary spermatocytes, based on measuring all genes or a set of broadly expressed genes in testis we identified. In contrast, genes on the single Y chromosome become maximally active in primary spermatocytes. Reduced X transcript levels are due to failed activation of RNA-Polymerase-II by phosphorylation of Serine 2 and 5.-
Descrição: dc.descriptionNational Institute of Diabetes and Digestive and Kidney Diseases-
Descrição: dc.descriptionLaboratory of Cellular and Developmental Biology National Institute of Diabetes and Kidney and Digestive Diseases National Institutes of Health-
Descrição: dc.descriptionDepartment of Cell Biology Johns Hopkins University School of Medicine, 725 N. Wolfe Street-
Descrição: dc.descriptionCell Biology and Physiology Center National Heart Lung and Blood Institute National Institutes of Health-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology Institute of Biosciences University of São Paulo-
Descrição: dc.descriptionInstituto de Biociências/IB Departamento de Biologia Geral e Aplicada UNESP—Universidade Estadual Paulista Rio Claro-
Descrição: dc.descriptionLaboratory of Muscle Stem Cells and Gene Regulation National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health-
Descrição: dc.descriptionGenomics Core National Institute of Diabetes and Kidney and Digestive Diseases National Institutes of Health-
Descrição: dc.descriptionDepartment of Evolutionary Biology and Department of Organismal Biology Systematic Biology Evolutionary Biology Centre Uppsala University-
Descrição: dc.descriptionDepartment of Pharmacology Feinberg School of Medicine Northwestern University-
Descrição: dc.descriptionInstituto de Biociências/IB Departamento de Biologia Geral e Aplicada UNESP—Universidade Estadual Paulista Rio Claro-
Descrição: dc.descriptionNational Institute of Diabetes and Digestive and Kidney Diseases: DK015600-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleDynamic sex chromosome expression in Drosophila male germ cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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