Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorOeste Paulista University (UNOESTE)-
Autor(es): dc.creatorMatias, Mariana Leticia [UNESP]-
Autor(es): dc.creatorRomao-Veiga, Mariana [UNESP]-
Autor(es): dc.creatorRibeiro, Vanessa Rocha [UNESP]-
Autor(es): dc.creatorNunes, Priscila Rezeck [UNESP]-
Autor(es): dc.creatorGomes, Virginia Juliani [UNESP]-
Autor(es): dc.creatorDevides, Amanda Carreira [UNESP]-
Autor(es): dc.creatorBorges, Vera Therezinha [UNESP]-
Autor(es): dc.creatorRomagnoli, Graziela Goretti-
Autor(es): dc.creatorPeracoli, Jose Carlos [UNESP]-
Autor(es): dc.creatorPeracoli, Maria Terezinha [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jri.2021.103286-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207259-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207259-
Descrição: dc.descriptionThis study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-κB pathway in monocytes from pregnant women with preeclampsia (PE). Monocytes from 20 preeclamptic and 20 normotensive (NT) pregnant women, and THP-1 cells were cultured with/without hyaluronan (HA), PG, or VD to determine gene and protein expression of TLR4 receptor, phosphorylated NF-κB, IκBα, TLR4, MYD88, NF-κB, NLRP1, NLRP3, caspase-1, IL-1β, IL-18, TNF-α, and IL-10. Higher endogenous activation of inflammatory genes and higher protein expression of TLR4 and NF-κB was detected in monocytes of PE group and decreased after PG or VD treatment. Monocyte from PE stimulated with HA increased while treatment with PG or VD decreased the expression of genes and proteins related to the inflammasomes. THP-1 cells showed a similar immune response profile as monocytes from PE. These results demonstrate that PG and VD play an immunomodulatory role in monocyte activation.-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment Health Science Oeste Paulista University (UNOESTE)-
Descrição: dc.descriptionDepartment of Chemistry and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP), Botucatu-
Idioma: dc.languageen-
Relação: dc.relationJournal of Reproductive Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMonocytes-
Palavras-chave: dc.subjectNLRP1/NLRP3 inflammasomes-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectProgesterone-
Palavras-chave: dc.subjectVitamin D-
Título: dc.titleProgesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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