Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil

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Autor(es): dc.contributorFederal University of Rio de Janeiro-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorEscola Paulista de Medicina-
Autor(es): dc.contributorUniversidade Federal do Parana-
Autor(es): dc.contributorKaiser Day Hospital-
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul-
Autor(es): dc.contributorFaculdade de Medicina do ABC-
Autor(es): dc.contributorFederal University of Piaui-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorHospital Nossa Senhora das Graças-
Autor(es): dc.contributorKaiser Hospital Dia-
Autor(es): dc.contributorState University of Piaui-
Autor(es): dc.contributorCMIP Centro Mineiro de Pesquisa-
Autor(es): dc.contributorTakeda Pharmaceuticals Brazil-
Autor(es): dc.contributorUniversity of Juiz de Fora-
Autor(es): dc.creatorZaltman, Cyrla-
Autor(es): dc.creatorParra, Rogério Serafim-
Autor(es): dc.creatorSassaki, Ligia Yukie [UNESP]-
Autor(es): dc.creatorSantana, Genoile Oliveira-
Autor(es): dc.creatorde Lourdes Abreu Ferrari, Maria-
Autor(es): dc.creatorMiszputen, Sender J.-
Autor(es): dc.creatorAmarante, Heda M.B.S.-
Autor(es): dc.creatorKaiser, Roberto Luiz-
Autor(es): dc.creatorFlores, Cristina-
Autor(es): dc.creatorCatapani, Wilson R.-
Autor(es): dc.creatorParente, José Miguel Luz-
Autor(es): dc.creatorBafutto, Mauro-
Autor(es): dc.creatorRamos, Odery-
Autor(es): dc.creatorGonçalves, Carolina D.-
Autor(es): dc.creatorGuimaraes, Isabella Miranda-
Autor(es): dc.creatorda Rocha, Jose J.R.-
Autor(es): dc.creatorFeitosa, Marley R.-
Autor(es): dc.creatorFeres, Omar-
Autor(es): dc.creatorSaad-Hossne, Rogerio [UNESP]-
Autor(es): dc.creatorPenna, Francisco Guilherme Cancela-
Autor(es): dc.creatorCunha, Pedro Ferrari Sales-
Autor(es): dc.creatorGomes, Tarcia N.F.-
Autor(es): dc.creatorNones, Rodrigo Bremer-
Autor(es): dc.creatorFaria, Mikaell Alexandre Gouvea-
Autor(es): dc.creatorDias Parente, Mírian Perpétua Palha-
Autor(es): dc.creatorScotton, António S.-
Autor(es): dc.creatorCaratin, Rosana Fusaro-
Autor(es): dc.creatorSenra, Juliana-
Autor(es): dc.creatorChebli, Júlio Maria-
Data de aceite: dc.date.accessioned2022-02-22T00:49:39Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:39Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3748/WJG.V27.I2.208-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207247-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207247-
Descrição: dc.descriptionBACKGROUND Understanding the treatment landscape of inflammatory bowel diseases (IBD) is essential for improving disease management and patient outcomes. Brazil is the largest Latin American country, and it presents socioeconomic and health care differences across its geographical regions. This country has the highest increase in IBD incidence and prevalence in Latin America, but information about the clinical and treatment characteristics of IBD is scarce. AIM To describe the sociodemographic, clinical, and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast, South and Northeast/Midwest regions. METHODS Multicenter, cross-sectional study with a 3-year retrospective chart review component. Patients with moderate-to-severe Crohn's disease (CD) or ulcerative colitis (UC) were consecutively enrolled between October 2016 and February 2017. Active CD at enrollment was defined as a Harvey Bradshaw Index ≥ 8 or a CD Activity Index ≥ 220 or a calprotectin level > 200 μg/g or an active result based on colonoscopy suggestive of inadequate control during the previous year; active UC was defined as a partial Mayo score ≥ 5. Descriptive statistics were used to analyze all variables. RESULTS In a total of 407 included patients, CD was more frequent than UC, both overall (264 CD/143 UC patients) and by region (CD:UC ratios of 2.1 in the Southeast, 1.6 in the South and 1.2 in the Northeast/Midwest). The majority of patients were female (54.2% of CD; 56.6% of UC), and the mean ages were 45.9 ± 13.8 years (CD) and 42.9 ± 13.0 years (UC). The median disease duration was 10.0 (range: 0.5-45) years for both IBD types. At enrollment, 44.7% [95% confidence interval (CI): 38.7-50.7] of CD patients and 25.2% (95%CI: 18.1-32.3) of UC patients presented with active disease. More than 95% of IBD patients were receiving treatment at enrollment; CD patients were commonly treated with biologics (71.6%) and immunosuppressors (67.4%), and UC patients were commonly treated with mesalazine [5-Aminosalicylic acid (5-ASA)] derivates (69.9%) and immunosuppressors (44.1%). More than 50% of the CD patients had ileocolonic disease, and 41.7% presented with stricturing disease. One-quarter of CD patients had undergone CD-related surgery in the past 3 years, and this proportion was lower in the Northeast/Midwest region (2.9%). CONCLUSION In Brazil, there are regional variations in IBD management. CD outweighs UC in both frequency and disease activity. However, one-quarter of UC patients have active disease, and most are receiving 5-ASA treatment.-
Descrição: dc.descriptionDepartment of Internal Medicine Federal University of Rio de Janeiro-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (UNESP) Medical School-
Descrição: dc.descriptionIBD Unit Federal University of Bahia-
Descrição: dc.descriptionDepartment of Clinical Medicine Medical School Universidade Federal de Minas Gerais-
Descrição: dc.descriptionDepartment of Gastroenterology Escola Paulista de Medicina-
Descrição: dc.descriptionHospital de Clinicas Universidade Federal do Parana-
Descrição: dc.descriptionDepartment of Proctology Beneficencia Portuguesa Hospital Kaiser Day Hospital-
Descrição: dc.descriptionDepartment of Gastroenterology and Hepatology Sciences Hospital de Clínicas Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Gastroenterology Faculdade de Medicina do ABC-
Descrição: dc.descriptionDepartment of General Medicine Gastroenterology Unit University Hospital Federal University of Piaui-
Descrição: dc.descriptionDepartment of Gastroenterology Faculdade de Medicina Universidade Federal de Goiás-
Descrição: dc.descriptionDepartment of Surgery Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gastroenterology UNIFESP-
Descrição: dc.descriptionIBD Unit Gastroenterology Department Hospital Nossa Senhora das Graças-
Descrição: dc.descriptionDepartment of Proctology Kaiser Hospital Dia-
Descrição: dc.descriptionHealth Sciences Center Epidemiology Unit State University of Piaui-
Descrição: dc.descriptionDepartment of Gastroenterology CMIP Centro Mineiro de Pesquisa-
Descrição: dc.descriptionScientific Affairs Takeda Pharmaceuticals Brazil-
Descrição: dc.descriptionClinical Research Takeda Pharmaceuticals Brazil-
Descrição: dc.descriptionDepartment of Medicine University Hospital of Federal University of Juiz de Fora-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (UNESP) Medical School-
Descrição: dc.descriptionDepartment of Surgery Botucatu Medical School São Paulo State University (UNESP)-
Formato: dc.format208-223-
Idioma: dc.languageen-
Relação: dc.relationWorld Journal of Gastroenterology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCrohn's disease-
Palavras-chave: dc.subjectDisease activity-
Palavras-chave: dc.subjectEpidemiology-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectTreatment-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleReal-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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