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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | de Oliveira, Guillermo C.V. [UNESP] | - |
Autor(es): dc.creator | Teixeira-Neto, Francisco J. [UNESP] | - |
Autor(es): dc.creator | Dalmagro, Tábata L. [UNESP] | - |
Autor(es): dc.creator | Alfonso, Angélica [UNESP] | - |
Autor(es): dc.creator | Celeita-Rodríguez, Nathalia [UNESP] | - |
Autor(es): dc.creator | Lobo, César P.C. [UNESP] | - |
Autor(es): dc.creator | Lourenço, Maria L.G. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:49:35Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:49:35Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-03-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.vaa.2020.12.006 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207229 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207229 | - |
Descrição: dc.description | Objective: To evaluate the ability of transthoracic echocardiographic aortic flow measurements to discriminate response to a fluid challenge (FC) in healthy anesthetized dogs. Study design: Prospective experimental study. Animals: A total of 48 isoflurane-anesthetized dogs (14.2–35.0 kg) undergoing elective surgery. Methods: Fluid responsiveness was evaluated before surgery by FC (lactated Ringer's 10 mL kg–1 intravenously over 5 minutes). Percentage increases in transpulmonary thermodilution stroke volume (ΔSVTPTD) >15% from values recorded before FC defined responders to volume expansion. A group of 24 animals were assigned as nonresponders (ΔSVTPTD ≤15%). When ΔSVTPTD was >15% after the first FC, additional FC were administered until ΔSVTPTD was ≤15%. Final fluid responsiveness status was based on the response to the last FC. Percentage increases after FC in aortic flow indexes [velocity time integral (ΔVTIFC) and maximum acceleration (ΔVmaxFC)] and in mean arterial pressure (ΔMAPFC) were compared with ΔSVTPTD. Results: After one FC, 24 animals were responders. For nonresponders, ΔSVTPTD was ≤15% after one, two and three FCs in eight/24, 15/24 and one/24 animals, respectively. The FC that defined responsiveness increased ΔSVTPTD by 29 (18–53)% in responders and by 8 (–3 to 15)% in nonresponders [mean (range)]. The area under the receiver operating characteristics curve (AUROC) of ΔVTIFC (0.901) was larger than the AUROCs of ΔVmaxFC (0.774, p = 0.041) and ΔMAPFC (0.519, p < 0.0001). ΔMAPFC did not predict responsiveness (p = 0.826). Best cut-off thresholds for discriminating responders, with respective zones of diagnostic uncertainty (gray zones) were >14.7 (10.8–17.6)% for ΔVTIFC and >8.6 (–0.3 to 14.7)% for ΔVmaxFC. Animals within the gray zone were 17% (ΔVTIFC) and 50% (ΔVmaxFC). Conclusions and clinical relevance: Changes in VTI induced by FC can determine responsiveness with reasonable accuracy in dogs and could play an important role in goal-directed fluid therapy. | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) | - |
Descrição: dc.description | Department of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP) | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) | - |
Descrição: dc.description | Department of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP) | - |
Formato: dc.format | 187-197 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Veterinary Anaesthesia and Analgesia | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | fluid responsiveness | - |
Palavras-chave: dc.subject | goal-directed fluid therapy | - |
Palavras-chave: dc.subject | velocity time integral | - |
Título: dc.title | Use of aortic flow indexes derived from transthoracic echocardiography to evaluate response to a fluid challenge in anesthetized dogs | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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