Use of aortic flow indexes derived from transthoracic echocardiography to evaluate response to a fluid challenge in anesthetized dogs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Oliveira, Guillermo C.V. [UNESP]-
Autor(es): dc.creatorTeixeira-Neto, Francisco J. [UNESP]-
Autor(es): dc.creatorDalmagro, Tábata L. [UNESP]-
Autor(es): dc.creatorAlfonso, Angélica [UNESP]-
Autor(es): dc.creatorCeleita-Rodríguez, Nathalia [UNESP]-
Autor(es): dc.creatorLobo, César P.C. [UNESP]-
Autor(es): dc.creatorLourenço, Maria L.G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:35Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vaa.2020.12.006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207229-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207229-
Descrição: dc.descriptionObjective: To evaluate the ability of transthoracic echocardiographic aortic flow measurements to discriminate response to a fluid challenge (FC) in healthy anesthetized dogs. Study design: Prospective experimental study. Animals: A total of 48 isoflurane-anesthetized dogs (14.2–35.0 kg) undergoing elective surgery. Methods: Fluid responsiveness was evaluated before surgery by FC (lactated Ringer's 10 mL kg–1 intravenously over 5 minutes). Percentage increases in transpulmonary thermodilution stroke volume (ΔSVTPTD) >15% from values recorded before FC defined responders to volume expansion. A group of 24 animals were assigned as nonresponders (ΔSVTPTD ≤15%). When ΔSVTPTD was >15% after the first FC, additional FC were administered until ΔSVTPTD was ≤15%. Final fluid responsiveness status was based on the response to the last FC. Percentage increases after FC in aortic flow indexes [velocity time integral (ΔVTIFC) and maximum acceleration (ΔVmaxFC)] and in mean arterial pressure (ΔMAPFC) were compared with ΔSVTPTD. Results: After one FC, 24 animals were responders. For nonresponders, ΔSVTPTD was ≤15% after one, two and three FCs in eight/24, 15/24 and one/24 animals, respectively. The FC that defined responsiveness increased ΔSVTPTD by 29 (18–53)% in responders and by 8 (–3 to 15)% in nonresponders [mean (range)]. The area under the receiver operating characteristics curve (AUROC) of ΔVTIFC (0.901) was larger than the AUROCs of ΔVmaxFC (0.774, p = 0.041) and ΔMAPFC (0.519, p < 0.0001). ΔMAPFC did not predict responsiveness (p = 0.826). Best cut-off thresholds for discriminating responders, with respective zones of diagnostic uncertainty (gray zones) were >14.7 (10.8–17.6)% for ΔVTIFC and >8.6 (–0.3 to 14.7)% for ΔVmaxFC. Animals within the gray zone were 17% (ΔVTIFC) and 50% (ΔVmaxFC). Conclusions and clinical relevance: Changes in VTI induced by FC can determine responsiveness with reasonable accuracy in dogs and could play an important role in goal-directed fluid therapy.-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP)-
Formato: dc.format187-197-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Anaesthesia and Analgesia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfluid responsiveness-
Palavras-chave: dc.subjectgoal-directed fluid therapy-
Palavras-chave: dc.subjectvelocity time integral-
Título: dc.titleUse of aortic flow indexes derived from transthoracic echocardiography to evaluate response to a fluid challenge in anesthetized dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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