Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.creatorJorge, Bárbara Campos [UNESP]-
Autor(es): dc.creatorReis, Ana Carolina Casali [UNESP]-
Autor(es): dc.creatorStein, Julia [UNESP]-
Autor(es): dc.creatorBalin, Paola da Silva [UNESP]-
Autor(es): dc.creatorSterde, Érika Tissiana [UNESP]-
Autor(es): dc.creatorBarbosa, Mariana Gazoli [UNESP]-
Autor(es): dc.creatorde Aquino, Ariana Musa [UNESP]-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:34Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:34Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2021.01.011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207221-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207221-
Descrição: dc.descriptionBenzo(a)pyrene (BaP) is an ubiquitous environmental pollutant which can lead to adverse effects on male reproduction. However, the persistence of these changes on a multigenerational scale has not been sufficiently explored. This study evaluated if peripubertal exposure to BaP in male rats can induce reproductive impairment in offspring. Male rats received BaP at environmentally relevant doses (0, 0.1, 1, or 10 μg/kg/day) orally from post-natal (PND) 23–53. On PND 90, treated males were mated with non-treated females for obtaining the next generation (F1). The paternal exposure to BaP decreased the body weight of offspring on PND 1, 13 and 22, as well as it provoked a reduction in the relative anogenital distance of the males. This exposure also brought forward the onset of puberty, evidenced by an earlier vaginal opening and first estrous in females of the lowest dose group and by a delay in the testicular descent and preputial separation ages in males. The males presented a decrease in the daily sperm production and a disrupted sperm morphology. Furthermore, the testicular histology was altered, evidenced by a reduction in the Leydig cell numbers and in the seminiferous tubules diameter, as well as a disrupted seminiferous tubules staging. The estrous cyclicity and some fertility parameters were changed in the females, as well as alterations in the ovary and uterus histology were observed. BaP compromised several reproductive parameters of the F1 generation, suggesting that peripubertal exposure to this compound provokes permanent modifications in male germ line of F0 generation.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionCollege of Health Science Federal University of Grande Dourados-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Formato: dc.format126-136-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocrine disruptor-
Palavras-chave: dc.subjectFertility-
Palavras-chave: dc.subjectOffspring-
Palavras-chave: dc.subjectPaternal programming-
Palavras-chave: dc.subjectPolycyclic aromatic hydrocarbons-
Título: dc.titleParental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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