Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential

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Autor(es): dc.contributorUniversity of Araraquara (UNIARA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNanobiotechnology Laboratory-
Autor(es): dc.contributorUNIARA Carlos Gomes 1338-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorGirotto, Luiza-
Autor(es): dc.creatorSaldanha, Luiz Leonardo [UNESP]-
Autor(es): dc.creatorRamos, Matheus Aparecido Dos Santos [UNESP]-
Autor(es): dc.creatorDe Grandis, Rone Aparecido [UNESP]-
Autor(es): dc.creatorDa Silva, Patrícia Bento [UNESP]-
Autor(es): dc.creatorDokkedal, Anne Lígia [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorBauab, Tais Maria [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Autor(es): dc.creatorTrovatti, Eliane-
Autor(es): dc.creatorLustri, Wilton Rogério-
Autor(es): dc.creatorResende, Flávia Ap.-
Data de aceite: dc.date.accessioned2022-02-22T00:49:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:33Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/a-1323-3622-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207215-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207215-
Descrição: dc.descriptionMyrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M. bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M. bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M. bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M. bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp.-
Descrição: dc.descriptionUniversity of Araraquara (UNIARA) Department of Biological Sciences and Health-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biological Sciences Faculty of Science-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biological Sciences School of Pharmaceutical Sciences, Campus Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Campus Araraquara-
Descrição: dc.descriptionUniversity of Brasilia Nanobiotechnology Laboratory Department of Genetics and Morphology-
Descrição: dc.descriptionUniversity of Araraquara Department of Biological Sciences and Health UNIARA Carlos Gomes 1338, Rua Carlos Gomes, 1217-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biological Sciences Faculty of Science-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biological Sciences School of Pharmaceutical Sciences, Campus Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Campus Araraquara-
Idioma: dc.languageen-
Relação: dc.relationPlanta Medica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectbiopharmaceuticals-
Palavras-chave: dc.subjectbiotechnology-
Palavras-chave: dc.subjectmutagenicity-
Palavras-chave: dc.subjectMyrcia bella-
Palavras-chave: dc.subjectMyrtaceae-
Palavras-chave: dc.subjectnanotechnology-
Título: dc.titleHydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential-
Tipo de arquivo: dc.typelivro digital-
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