Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Université Laval | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Marques, Danuzia A. | - |
Autor(es): dc.creator | Gargaglioni, Luciane H. [UNESP] | - |
Autor(es): dc.creator | Joseph, Vincent | - |
Autor(es): dc.creator | Bretzner, Frédéric | - |
Autor(es): dc.creator | Bícego, Kênia C. [UNESP] | - |
Autor(es): dc.creator | Fournier, Stéphanie | - |
Autor(es): dc.creator | Kinkead, Richard | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:49:31Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:49:31Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.brainres.2021.147276 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207205 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207205 | - |
Descrição: dc.description | The neural network that regulates breathing shows a significant sexual dimorphism. Ovarian hormones contribute to this distinction as, in rats, ovariectomy reduces the ventilatory response to CO2. Microglia are neuroimmune cells that are sensitive to neuroendocrine changes in their environment. When reacting to challenging conditions, these cells show changes in their morphology that reflect an augmented capacity for producing pro- and anti-inflammatory cytokines. Based on evidence suggesting that microglia contribute to sex-based differences in reflexive responses to hypercapnia, we hypothesized that ovariectomy and hypercapnia promote microglial reactivity in selected brain areas that regulate breathing. We used ionized calcium-binding-adapter molecule-1 (Iba1) immunolabeling to compare the density and morphology of microglia in the locus coeruleus (LC), the caudal medullary raphe, the caudal part of the nucleus of the tractus solitarius (cNTS), and the paraventricular nucleus of the hypothalamus (PVN). Tissue was obtained from SHAM (metaestrus) female rats or following ovariectomy. Rats were exposed to normocapnia or hypercapnia (5% CO2, 20 min). Ovariectomy and hypercapnia did not affect microglial density in any of the structures studied. Ovariectomy promoted a reactive phenotype in the cNTS and LC, as indicated by a larger morphological index. In these structures, hypercapnia had a relatively modest opposing effect; the medullary raphe or the PVN were not affected. We conclude that ovarian hormones attenuate microglial reactivity in CO2/H+ sensing structures. These data suggest that microglia may contribute to neurological diseases in which anomalies of respiratory control are associated with cyclic fluctuations of ovarian hormones or menopause. | - |
Descrição: dc.description | Département de Pédiatrie Centre de Recherche de l'Institut Universitaire de Cardiologie et Pneumologie de Québec Université Laval | - |
Descrição: dc.description | Department of Animal Morphology and Physiology Sao Paulo State University UNESP/FCAV at Jaboticabal | - |
Descrição: dc.description | Département de Psychiatrie et Neurosciences Centre de Recherche du CHU de Québec Université Laval | - |
Descrição: dc.description | Department of Animal Morphology and Physiology Sao Paulo State University UNESP/FCAV at Jaboticabal | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Brain Research | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Chemosensitivity | - |
Palavras-chave: dc.subject | Hypothalamus | - |
Palavras-chave: dc.subject | Medulla | - |
Palavras-chave: dc.subject | Neuroinflammation | - |
Palavras-chave: dc.subject | Pons | - |
Palavras-chave: dc.subject | Sex hormones | - |
Título: dc.title | Impact of ovariectomy and CO2 inhalation on microglia morphology in select brainstem and hypothalamic areas regulating breathing in female rats | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: