Swimming Program on Mildly Diabetic Rats in Pregnancy

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Autor(es): dc.contributorSouthwest Paulista University Center (Unifsp)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMacedo, Nathália C. D.-
Autor(es): dc.creatorIessi, Isabela L.-
Autor(es): dc.creatorGallego, Franciane Q.-
Autor(es): dc.creatorNetto, Aline O.-
Autor(es): dc.creatorSinzato, Yuri K.-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorDamasceno, Débora C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:28Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-021-00462-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207183-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207183-
Descrição: dc.descriptionThe present study aims to confirm if the moderate-intensity swimming has successful glycemic control and non-toxic oxidative stress levels and to verify the influence on pancreatic adaptations, embryo implantation, and placental efficiency. Female Wistar rats were randomly distributed to obtain mildly diabetic by streptozotocin induction at birth and the non-diabetic females given vehicle. At adulthood, pregnant rats were put at random into sedentary non-diabetic rats (ND); exercise non-diabetic rats (NDEx); sedentary diabetic rats (D); and exercise diabetic rats (DEx). The rats of the groups submitted to moderate intensity carried loads equivalent to 4% of body weight. On day 17 of gestational day, all rats were submitted to oral glucose tolerance test (OGTT). Next day (GD18), the rats were anesthetized and killed to count implantation sites and to collect placentas, blood, and muscle samples for biochemical biomarkers and pancreas for immunohistochemical analysis. The moderate exercise used was not sufficient to stimulate the aerobic pathway but presented positive results on glucose metabolism, lower embryo postimplantation loss, and pancreatic morphology compared with the sedentary diabetic group. However, the DEx group showed muscular damage, decreased antioxidant defense, and lipid peroxidation. Thus, the moderate-intensity exercise reduces glycemic levels during OGTT and causes no damage to non-diabetic rats related to other analyzed parameters in this study. The exercised diabetic rats present better glycemic metabolism in OGTT, islet pancreatic morphology, and embryofetal development. However, it is necessary an adjustment in this exercise intensity to improve the effectiveness of aerobic training for reduction of maternal muscular and lipid membrane damages.-
Descrição: dc.descriptionSouthwest Paulista University Center (Unifsp)-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionDepartamento de Biología de la Reproducción Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Program on Tocogynecology Botucatu Medical School Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Program on Tocogynecology Botucatu Medical School Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectModerate exercise-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPancreatic islets-
Palavras-chave: dc.subjectPregnancy-
Palavras-chave: dc.subjectRats-
Título: dc.titleSwimming Program on Mildly Diabetic Rats in Pregnancy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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