Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCorteva Agriscience-
Autor(es): dc.creatorLima, Thania Rios Rossi [UNESP]-
Autor(es): dc.creatorSales, Bianca Camargo Penteado [UNESP]-
Autor(es): dc.creatorCatalano, Shadia Muhammad Ihlaseh-
Data de aceite: dc.date.accessioned2022-02-22T00:49:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:24Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/978-1-0716-1091-6_8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207165-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207165-
Descrição: dc.descriptionThe urinary bladder is a target organ of several toxic agents. Exposure to those agents induces mild-to-severe changes, which can be evaluated by different methods. Among them, the scanning-electron microscopy (SEM) is the “gold standard” for characterizing urothelial damage since it provides high-definition images, making it possible to detect early lesions on the surface of the urinary bladder. In addition, molecular technologies allow detecting changes in genetic material and investigating the interaction between genes and environmental stress in disease causation. The urinary bladder epithelium is where the most common type of bladder cancer occurs in humans, that is, the transitional-cell carcinoma (TCC). In animal models, the TCC can be similar to the disease in humans. Techniques to evaluate urothelium in experimental models aid in the comprehension of risk factors for urothelial carcinogenesis.-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM) São Paulo State University (UNESP)-
Descrição: dc.descriptionRegulatory Toxicology and Risk Corteva Agriscience-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM) São Paulo State University (UNESP)-
Formato: dc.format93-102-
Idioma: dc.languageen-
Relação: dc.relationMethods in Molecular Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectEpithelial cells-
Palavras-chave: dc.subjectIn vivo-
Palavras-chave: dc.subjectMolecular biology-
Palavras-chave: dc.subjectScanning-electron microscopy-
Palavras-chave: dc.subjectUrinary bladder-
Título: dc.titleAssessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ-
Aparece nas coleções:Repositório Institucional - Unesp

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