Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution

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Autor(es): dc.contributorUniversidade Estadual do Norte do Paraná – UENP-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversity of Manitoba-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorde Morais, Juliana Maria Bitencourt-
Autor(es): dc.creatorCruz, Ellen Mayara Souza-
Autor(es): dc.creatorda Rosa, Carlos Vinícius Dalto-
Autor(es): dc.creatorCesário, Roberta Carvalho [UNESP]-
Autor(es): dc.creatorComar, Jurandir Fernando-
Autor(es): dc.creatorMoreira, Carolina Campos Lima-
Autor(es): dc.creatorde Almeida Chuffa, Luiz Gustavo [UNESP]-
Autor(es): dc.creatorSeiva, Fábio Rodrigues Ferreira-
Data de aceite: dc.date.accessioned2022-02-22T00:49:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.119048-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207140-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207140-
Descrição: dc.descriptionAims: The present study investigated the potential effects of pterostilbene (PT) on glycemic and lipid profiles, fat storage, cardiovascular indices, and hepatic parameters of rats fed with sucrose solution. Main methods: 24 male Wistar rats received either drinking water or a 40% sucrose solution over a period of 140 days. After this period, animals were randomly allocated into four groups (n = 6): Control (C), C + Pterostilbene (PT), Sucrose (S), and S + PT. Pterostilbene (40 mg/kg) was given orally for 45 consecutive days. Key findings: Pterostilbene did not influence morphometric and nutritional parameters. The insulin sensitivity index TyG was elevated in the C + PT group (p < 0.01) and reduced in S + PT group (p < 0.05). Basal glucose levels were lower in the S + PT group (p < 0.05), and the glycemic response was improved with PT treatment in glucose provocative tests. Conversely, rats from the C + PT group showed impaired glucose disposal during those tests. Lipid profile was partially improved by PT treatment. Hepatic oxidative stress in the S group was improved after PT treatment. In the C group, PT reduced SOD activity, glutathione levels, and increased catalase activity. Collagen content was reduced by PT treatment. Significance: PT effects depends on the type of diet the animals were submitted. In rats fed with sucrose-solution, PT confirmed its positive effects, improving glucose and lipid profile, and acting as a potent antioxidant. The effects of PT on rats that consumed a normal diet were very discrete or even undesirable. We suggest caution with indiscriminate consume of natural compounds by healthy subjects.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biology Biological Science Center Universidade Estadual do Norte do Paraná – UENP, Luiz Meneghel Campus-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - UNESP-
Descrição: dc.descriptionDepartment of Biochemistry Universidade Estadual de Maringá – UEM-
Descrição: dc.descriptionDepartment of Immunology University of Manitoba-
Descrição: dc.descriptionPost Graduation Program of Experimental Pathology Universidade Estadual de Londrina – UEL-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - UNESP-
Descrição: dc.descriptionCNPq: 05/2018 – CIC/PROPG/UENP-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHepatic tissue-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPolyphenol-
Palavras-chave: dc.subjectSugar-enriched beverage-
Título: dc.titlePterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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