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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual do Norte do Paraná – UENP | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Maringá (UEM) | - |
Autor(es): dc.contributor | University of Manitoba | - |
Autor(es): dc.contributor | Universidade Estadual de Londrina (UEL) | - |
Autor(es): dc.creator | de Morais, Juliana Maria Bitencourt | - |
Autor(es): dc.creator | Cruz, Ellen Mayara Souza | - |
Autor(es): dc.creator | da Rosa, Carlos Vinícius Dalto | - |
Autor(es): dc.creator | Cesário, Roberta Carvalho [UNESP] | - |
Autor(es): dc.creator | Comar, Jurandir Fernando | - |
Autor(es): dc.creator | Moreira, Carolina Campos Lima | - |
Autor(es): dc.creator | de Almeida Chuffa, Luiz Gustavo [UNESP] | - |
Autor(es): dc.creator | Seiva, Fábio Rodrigues Ferreira | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:49:20Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:49:20Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-03-15 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.lfs.2021.119048 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207140 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207140 | - |
Descrição: dc.description | Aims: The present study investigated the potential effects of pterostilbene (PT) on glycemic and lipid profiles, fat storage, cardiovascular indices, and hepatic parameters of rats fed with sucrose solution. Main methods: 24 male Wistar rats received either drinking water or a 40% sucrose solution over a period of 140 days. After this period, animals were randomly allocated into four groups (n = 6): Control (C), C + Pterostilbene (PT), Sucrose (S), and S + PT. Pterostilbene (40 mg/kg) was given orally for 45 consecutive days. Key findings: Pterostilbene did not influence morphometric and nutritional parameters. The insulin sensitivity index TyG was elevated in the C + PT group (p < 0.01) and reduced in S + PT group (p < 0.05). Basal glucose levels were lower in the S + PT group (p < 0.05), and the glycemic response was improved with PT treatment in glucose provocative tests. Conversely, rats from the C + PT group showed impaired glucose disposal during those tests. Lipid profile was partially improved by PT treatment. Hepatic oxidative stress in the S group was improved after PT treatment. In the C group, PT reduced SOD activity, glutathione levels, and increased catalase activity. Collagen content was reduced by PT treatment. Significance: PT effects depends on the type of diet the animals were submitted. In rats fed with sucrose-solution, PT confirmed its positive effects, improving glucose and lipid profile, and acting as a potent antioxidant. The effects of PT on rats that consumed a normal diet were very discrete or even undesirable. We suggest caution with indiscriminate consume of natural compounds by healthy subjects. | - |
Descrição: dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
Descrição: dc.description | Department of Biology Biological Science Center Universidade Estadual do Norte do Paraná – UENP, Luiz Meneghel Campus | - |
Descrição: dc.description | Department of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - UNESP | - |
Descrição: dc.description | Department of Biochemistry Universidade Estadual de Maringá – UEM | - |
Descrição: dc.description | Department of Immunology University of Manitoba | - |
Descrição: dc.description | Post Graduation Program of Experimental Pathology Universidade Estadual de Londrina – UEL | - |
Descrição: dc.description | Department of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - UNESP | - |
Descrição: dc.description | CNPq: 05/2018 – CIC/PROPG/UENP | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Life Sciences | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Hepatic tissue | - |
Palavras-chave: dc.subject | Oxidative stress | - |
Palavras-chave: dc.subject | Polyphenol | - |
Palavras-chave: dc.subject | Sugar-enriched beverage | - |
Título: dc.title | Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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