A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorRadboudumc-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorRadboudumc and Radboud Institute for Molecular Life Sciences (RIMLS)-
Autor(es): dc.creatorVerza, Beatriz S. [UNESP]-
Autor(es): dc.creatorvan den Beucken, Jeroen J.J.P.-
Autor(es): dc.creatorBrandt, João V. [UNESP]-
Autor(es): dc.creatorJafelicci Junior, Miguel [UNESP]-
Autor(es): dc.creatorBarão, Valentim A.R.-
Autor(es): dc.creatorPiazza, Rodolfo D. [UNESP]-
Autor(es): dc.creatorTagit, Oya-
Autor(es): dc.creatorSpolidorio, Denise M.P. [UNESP]-
Autor(es): dc.creatorVergani, Carlos Eduardo [UNESP]-
Autor(es): dc.creatorde Avila, Erica D. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:15Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:15Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2020.117604-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207114-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207114-
Descrição: dc.descriptionThis study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry at Araraquara São Paulo State University (UNESP), Humaita, 1680 Araraquara-
Descrição: dc.descriptionRegenerative Biomaterials Radboudumc, Philips Van Leydenlaan 25-
Descrição: dc.descriptionDepartment of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), Av. Limeira, 901-
Descrição: dc.descriptionDepartment of Tumor Immunology Radboudumc and Radboud Institute for Molecular Life Sciences (RIMLS), Geert Grooteplein Zuid, 28 Nijmegen-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry at Araraquara São Paulo State University (UNESP), Humaita, 1680 Araraquara-
Descrição: dc.descriptionDepartment of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2015/03567-7-
Descrição: dc.descriptionFAPESP: 2018/19345-1-
Idioma: dc.languageen-
Relação: dc.relationCarbohydrate Polymers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCoating-
Palavras-chave: dc.subjectCyclodextrin-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectLayer-By-Layer-
Palavras-chave: dc.subjectPercutaneous device-
Título: dc.titleA long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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