Regulation of anti-apoptotic sod2 and birc3 in periodontal cells and tissues

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Bonn-
Autor(es): dc.contributorUniversity of Mainz-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorZahnmedizinische Kliniken-
Autor(es): dc.contributorUniversity Medical Center-
Autor(es): dc.contributorUniversity of Regensburg-
Autor(es): dc.contributorFriedrich-Alexander University Erlangen-Nürnberg (FAU)-
Autor(es): dc.creatorRath-Deschner, Birgit-
Autor(es): dc.creatorNogueira, Andressa Vilas Boas-
Autor(es): dc.creatorMemmert, Svenja-
Autor(es): dc.creatorNokhbehsaim, Marjan-
Autor(es): dc.creatorCirelli, Joni Augusto [UNESP]-
Autor(es): dc.creatorEick, Sigrun-
Autor(es): dc.creatorMiosge, Nicolai-
Autor(es): dc.creatorKirschneck, Christian-
Autor(es): dc.creatorKesting, Marco-
Autor(es): dc.creatorDeschner, James-
Autor(es): dc.creatorJäger, Andreas-
Autor(es): dc.creatorDamanaki, Anna-
Data de aceite: dc.date.accessioned2022-02-22T00:49:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms22020591-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207106-
Descrição: dc.descriptionThe aim of the study was to clarify whether orthodontic forces and periodontitis interact with respect to the anti-apoptotic molecules superoxide dismutase 2 (SOD2) and baculoviral IAP repeat-containing protein 3 (BIRC3). SOD2, BIRC3, and the apoptotic markers caspases 3 (CASP3) and 9 (CASP9) were analyzed in gingiva from periodontally healthy and periodontitis subjects by real-time PCR and immunohistochemistry. SOD2 and BIRC3 were also studied in gingiva from rats with experimental periodontitis and/or orthodontic tooth movement. Additionally, SOD2 and BIRC3 levels were examined in human periodontal fibroblasts incubated with Fusobacterium nucle-atum and/or subjected to mechanical forces. Gingiva from periodontitis patients showed significantly higher SOD2, BIRC3, CASP3, and CASP9 levels than periodontally healthy gingiva. SOD2 and BIRC3 expressions were also significantly increased in the gingiva from rats with experimental periodontitis, but the upregulation of both molecules was significantly diminished in the concomitant presence of orthodontic tooth movement. In vitro, SOD2 and BIRC3 levels were significantly increased by F. nucleatum, but this stimulatory effect was also significantly inhibited by mechanical forces. Our study suggests that SOD2 and BIRC3 are produced in periodontal infection as a protective mechanism against exaggerated apoptosis. In the concomitant presence of orthodontic forces, this protective anti-apoptotic mechanism may get lost.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDeutscher Akademischer Austauschdienst-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft-
Descrição: dc.descriptionDepartment of Orthodontics Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionDepartment of Periodontology and Operative Dentistry University Medical Center University of Mainz-
Descrição: dc.descriptionDepartment of Orthodontics and Section of Experimental Dento-Maxillo-Facial Medicine Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionSection of Experimental Dento-Maxillo-Facial Medicine Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Periodontology Laboratory for Oral Microbiology zmk bern Zahnmedizinische Kliniken-
Descrição: dc.descriptionDepartment of Prosthodontics University Medical Center-
Descrição: dc.descriptionDepartment of Orthodontics University of Regensburg-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery Friedrich-Alexander University Erlangen-Nürnberg (FAU)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University UNESP-
Descrição: dc.descriptionFAPESP: 2017/07137-2-
Descrição: dc.descriptionDeutscher Akademischer Austauschdienst: 57391253-
Descrição: dc.descriptionCAPES: 88881.144012/2017-01-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: DE1593/5-1-
Formato: dc.format1-17-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFusobacterium nucleatum-
Palavras-chave: dc.subjectGingivitis-
Palavras-chave: dc.subjectOrthodontic tooth movement-
Palavras-chave: dc.subjectPeriodontal ligament-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPeriodontium-
Título: dc.titleRegulation of anti-apoptotic sod2 and birc3 in periodontal cells and tissues-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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