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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Polanco, X. B.J. | - |
Autor(es): dc.creator | Bertasso, A. S. | - |
Autor(es): dc.creator | Silveira, H. A. [UNESP] | - |
Autor(es): dc.creator | Yamamoto de Almeida, L. [UNESP] | - |
Autor(es): dc.creator | Almeida, L. K.Y. | - |
Autor(es): dc.creator | da Silva, R. A.B. | - |
Autor(es): dc.creator | da Silva, L. A.B. | - |
Autor(es): dc.creator | de Rossi, A. | - |
Autor(es): dc.creator | Nelson-Filho, P. | - |
Autor(es): dc.creator | León, J. E. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:49:12Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:49:12Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-05-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/iej.13464 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207097 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207097 | - |
Descrição: dc.description | Aim: To characterize plasma cell subsets in chronic periapical lesions affecting permanent and primary teeth. Methodology: Only chronic periapical lesions without root canal treatment were selected. Twenty-one radicular cysts and 7 periapical granulomas affecting permanent teeth and 19 radicular cysts and 4 periapical granulomas affecting primary teeth were assessed for immunoglobulin (Ig) light chain (kappa and lambda), Ig heavy chain (IgG, IgG4, IgA, IgM and IgD) and plasma cell immunohistochemical markers (MUM1/IRF4, EMA and CD138). The data acquired were analysed by Student’s t test, Mann–Whitney U, Friedman test followed by Dunn's multiple comparison test and Spearman’s rank correlation. Results: All cases were polyclonal (having similar kappa/lambda light chain ratios). IgG was most abundant compared to other Ig heavy chains (all, P < 0.001); like Ig light chains, but unlike IgA, there was greater expression of IgG in the primary compared to the permanent dentition, for both radicular cysts (P < 0.001) and periapical granulomas (P = 0.53). Notably, IgG4 expression was greater in the permanent than the primary dentition, for both radicular cyst (P < 0.05) and periapical granuloma (P = 0.65). IgM and IgD expression was scarce and variable, whereas plasma cell populations were detected efficiently through EMA, CD138 and MUM1/IRF4 markers, the latter being more sensitive in both dentitions. Conclusions: There were slight variations in the Ig light and heavy chain profiles in chronic periapical lesions when comparing the permanent and primary dentitions. The ability of IgG4+ plasma cell infiltration to modulate inflammatory responses in chronic periapical lesions arising from permanent as opposed to primary teeth should be considered in future studies. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Department of Pediatric Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo | - |
Descrição: dc.description | Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | Oral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo | - |
Descrição: dc.description | Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | FAPESP: 2016/02713-2 | - |
Descrição: dc.description | FAPESP: 2016/11419-0 | - |
Formato: dc.format | 682-692 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Endodontic Journal | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | deciduous teeth | - |
Palavras-chave: dc.subject | IgG4 | - |
Palavras-chave: dc.subject | Immunoglobulin | - |
Palavras-chave: dc.subject | Immunohistochemistry | - |
Palavras-chave: dc.subject | periapical lesion | - |
Palavras-chave: dc.subject | permanent teeth | - |
Título: dc.title | IgG4-positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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