IgG4-positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorPolanco, X. B.J.-
Autor(es): dc.creatorBertasso, A. S.-
Autor(es): dc.creatorSilveira, H. A. [UNESP]-
Autor(es): dc.creatorYamamoto de Almeida, L. [UNESP]-
Autor(es): dc.creatorAlmeida, L. K.Y.-
Autor(es): dc.creatorda Silva, R. A.B.-
Autor(es): dc.creatorda Silva, L. A.B.-
Autor(es): dc.creatorde Rossi, A.-
Autor(es): dc.creatorNelson-Filho, P.-
Autor(es): dc.creatorLeón, J. E.-
Data de aceite: dc.date.accessioned2022-02-22T00:49:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:12Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/iej.13464-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207097-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207097-
Descrição: dc.descriptionAim: To characterize plasma cell subsets in chronic periapical lesions affecting permanent and primary teeth. Methodology: Only chronic periapical lesions without root canal treatment were selected. Twenty-one radicular cysts and 7 periapical granulomas affecting permanent teeth and 19 radicular cysts and 4 periapical granulomas affecting primary teeth were assessed for immunoglobulin (Ig) light chain (kappa and lambda), Ig heavy chain (IgG, IgG4, IgA, IgM and IgD) and plasma cell immunohistochemical markers (MUM1/IRF4, EMA and CD138). The data acquired were analysed by Student’s t test, Mann–Whitney U, Friedman test followed by Dunn's multiple comparison test and Spearman’s rank correlation. Results: All cases were polyclonal (having similar kappa/lambda light chain ratios). IgG was most abundant compared to other Ig heavy chains (all, P < 0.001); like Ig light chains, but unlike IgA, there was greater expression of IgG in the primary compared to the permanent dentition, for both radicular cysts (P < 0.001) and periapical granulomas (P = 0.53). Notably, IgG4 expression was greater in the permanent than the primary dentition, for both radicular cyst (P < 0.05) and periapical granuloma (P = 0.65). IgM and IgD expression was scarce and variable, whereas plasma cell populations were detected efficiently through EMA, CD138 and MUM1/IRF4 markers, the latter being more sensitive in both dentitions. Conclusions: There were slight variations in the Ig light and heavy chain profiles in chronic periapical lesions when comparing the permanent and primary dentitions. The ability of IgG4+ plasma cell infiltration to modulate inflammatory responses in chronic periapical lesions arising from permanent as opposed to primary teeth should be considered in future studies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/02713-2-
Descrição: dc.descriptionFAPESP: 2016/11419-0-
Formato: dc.format682-692-
Idioma: dc.languageen-
Relação: dc.relationInternational Endodontic Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdeciduous teeth-
Palavras-chave: dc.subjectIgG4-
Palavras-chave: dc.subjectImmunoglobulin-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectperiapical lesion-
Palavras-chave: dc.subjectpermanent teeth-
Título: dc.titleIgG4-positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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