Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association–identified risk variants in a Southeastern Brazilian population

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes (UNILAGO)-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorCirelli, Thamiris [UNESP]-
Autor(es): dc.creatorNepomuceno, Rafael [UNESP]-
Autor(es): dc.creatorGoveia, Jéssica Marina [UNESP]-
Autor(es): dc.creatorOrrico, Silvana R. P. [UNESP]-
Autor(es): dc.creatorCirelli, Joni A. [UNESP]-
Autor(es): dc.creatorTheodoro, Letícia Helena [UNESP]-
Autor(es): dc.creatorBarros, Silvana P.-
Autor(es): dc.creatorScarel-Caminaga, Raquel M. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:05Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:05Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03717-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207063-
Descrição: dc.descriptionObjective: Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as genetic risk variants for these diseases in the Brazilian population. Material and methods: Periodontal, glycemic, and lipid data were obtained from 931 individuals divided into: control (n = 334), periodontitis (P; n = 358), and periodontitis associated with T2DM (P + T2DM; n = 239). After genotyping, associations between polymorphisms and pathologies were tested by multiple logistic and linear regressions, adjusting for age, sex, and smoking habits. Results: Considering the studied subjects, the increased risk to develop periodontitis in the periodontitis P + T2DM group was found for HNF1A-rs7957197-TA, CDKAL1-rs7754840-CG, RPSAP52-rs1531343-GC, TCF7L2-rs7903146-TT, and CDKN2B-rs7018475-GG. The association of these genetic variants for TCF7L2 and CDKN2B was confirmed for female, never smokers, and poorly controlled P + T2DM. CDKN2B-rs7018475 was associated with worse glycemic condition and periodontal parameters. Conclusion: These five reported genetic variants were associated in the studied Southeastern Brazilian population as genetic risk variants of periodontitis and T2DM associated to periodontitis as comorbidity. Gene–phenotype associations with sex and smoking habits and the CDKN2B-rs7018475 with the poor glycemic control and more severe periodontal conditions should be further investigated. Clinical relevance: Polymorphisms in the CDKAL1-rs7754840, HNF1A-rs7957197, RPSAP52-rs1531343, TCF7L2-rs7903146, and CDKN2B-rs7018475 might predispose to periodontitis and T2DM associated with periodontitis. These findings may be useful in public health genomics and future advanced clinical practice, since genetic carriage can be measured before disease onset, being of potential great benefit for treatment planning and prognosis in early disease stages.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionUnion of the Colleges of the Great Lakes (UNILAGO)-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University – UNESP School of Dentistry at Araçatuba-
Descrição: dc.descriptionDepartment of Comprehensive Oral Health – Periodontology University of North Carolina at Chapel Hill – UNC School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University – UNESP School of Dentistry at Araçatuba-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCDK5 regulatory subunit-associated protein 1-like 1-
Palavras-chave: dc.subjectCyclin-dependent kinase inhibitor 2B-
Palavras-chave: dc.subjectDiabetes mellitus type 2-
Palavras-chave: dc.subjectHepatocyte nuclear factor-1 alpha-
Palavras-chave: dc.subjectPeriodontal disease-
Palavras-chave: dc.subjectSingle-nucleotide polymorphism-
Título: dc.titleAssociation of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association–identified risk variants in a Southeastern Brazilian population-
Tipo de arquivo: dc.typelivro digital-
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