Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorda Silva Moreira, Suyane [UNESP]-
Autor(es): dc.creatorde Lima Inocêncio, Leonardo Cesar [UNESP]-
Autor(es): dc.creatorJorge, Bárbara Campos [UNESP]-
Autor(es): dc.creatorReis, Ana Carolina Casali [UNESP]-
Autor(es): dc.creatorHisano, Hamilton-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/tox.23085-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206999-
Descrição: dc.descriptionStudies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 μg/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 μg/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionEmbrapa Environment-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionFAPESP: #2018/07394-8-
Descrição: dc.descriptionFAPESP: #2018/07967-8-
Formato: dc.format831-839-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectorganogenesis-
Palavras-chave: dc.subjectpolycyclic aromatic hydrocarbon-
Palavras-chave: dc.subjectrats-
Palavras-chave: dc.subjectskeletal abnormalities-
Palavras-chave: dc.subjectteratogenicity-
Título: dc.titleEffects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.