Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Medicine of São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIntegrated College Padre Albino Foundation (FIPA)-
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorOswaldo Cruz Foundation (IGM-FIOCRUZ/BA)-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorFederal University of Paraiba-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorHenrique, Tiago-
Autor(es): dc.creatorZanon, Caroline de F. [UNESP]-
Autor(es): dc.creatorGirol, Ana P. [UNESP]-
Autor(es): dc.creatorStefanini, Ana Carolina Buzzo-
Autor(es): dc.creatorContessoto, Nayara S. de A. [UNESP]-
Autor(es): dc.creatorda Silveira, Nelson J. F.-
Autor(es): dc.creatorBezerra, Daniel P.-
Autor(es): dc.creatorSilveira, Edilberto R.-
Autor(es): dc.creatorBarbosa-Filho, José M.-
Autor(es): dc.creatorCornélio, Marinonio L. [UNESP]-
Autor(es): dc.creatorOliani, Sonia M. [UNESP]-
Autor(es): dc.creatorTajara, Eloiza H.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:51Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-78220-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206979-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206979-
Descrição: dc.descriptionChronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the present study, we investigated the physical and chemical interactions of PL with anti-inflammatory compounds and their effects on cell proliferation and migration and on the gene expression of inflammatory mediators. Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer. Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes. The results also suggested an inhibitory effect of PL on tubulin expression. In addition, PL apparently had no influence on cell migration and invasion at the concentration tested. Considering the role of inflammation in the context of promoting tumor initiation, the present study shows the potential of piplartine as a therapeutic immunomodulator for cancer prevention and progression.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Molecular Biology School of Medicine of São José do Rio Preto (FAMERP), Av Brigadeiro Faria Lima 5416-
Descrição: dc.descriptionDepartment of Biology São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) - Campus São José do Rio Preto, Cristóvão Colombo, 2265-
Descrição: dc.descriptionIntegrated College Padre Albino Foundation (FIPA)-
Descrição: dc.descriptionDepartment of Physics São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) - Campus São José do Rio Preto, Cristóvão Colombo, 2265-
Descrição: dc.descriptionLaboratory of Molecular Modeling and Computer Simulation/MolMod-CS Institute of Chemistry Federal University of Alfenas-
Descrição: dc.descriptionGonçalo Moniz Institute Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA)-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Ceará-
Descrição: dc.descriptionLaboratory of Pharmaceutics Technology Federal University of Paraiba-
Descrição: dc.descriptionDepartment of Genetics and Evolutive Biology Institute of Biosciences University of São Paulo-
Descrição: dc.descriptionDepartment of Biology São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) - Campus São José do Rio Preto, Cristóvão Colombo, 2265-
Descrição: dc.descriptionDepartment of Physics São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) - Campus São José do Rio Preto, Cristóvão Colombo, 2265-
Descrição: dc.descriptionCNPq: 142274/2014-3-
Descrição: dc.descriptionFAPESP: 2016/02012-4-
Descrição: dc.descriptionCNPq: 307327/2018-3-
Descrição: dc.descriptionCNPq: 308144/2014-7-
Descrição: dc.descriptionCNPq: 474596/2013-3-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleBiological and physical approaches on the role of piplartine (piperlongumine) in cancer-
Tipo de arquivo: dc.typelivro digital-
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