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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Justus-Liebig-University Giessen | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Pleuger, Christiane | - |
Autor(es): dc.creator | Silva, Erick José Ramo [UNESP] | - |
Autor(es): dc.creator | Pilatz, Adrian | - |
Autor(es): dc.creator | Bhushan, Sudhanshu | - |
Autor(es): dc.creator | Meinhardt, Andreas | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:48:48Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:48:48Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-11-26 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fimmu.2020.599594 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206976 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206976 | - |
Descrição: dc.description | The epididymis is a tubular structure connecting the vas deferens to the testis. This organ consists of three main regions—caput, corpus, and cauda—that face opposing immunological tasks. A means of combating invading pathogens is required in the distally located cauda, where there is a risk of ascending bacterial infections originating from the urethra. Meanwhile, immune tolerance is necessary at the caput, where spermatozoa with immunogenic neo-antigens originate from the testis. Consistently, when challenged with live bacteria or inflammatory stimuli, the cauda elicits a much stronger immune response and inflammatory-inflicted damage than the caput. At the cellular level, a role for diverse and strategically positioned mononuclear phagocytes is emerging. At the mechanistic level, differential expression of immunoprotective and immunomodulatory mediators has been detected between the three main regions of the epididymis. In this review, we summarize the current state of knowledge about region-specific immunological characteristics and unveil possible underlying mechanisms on cellular and molecular levels. Improved understanding of the different immunological microenvironments is the basis for an improved therapy and counseling of patients with epididymal infections. | - |
Descrição: dc.description | Deutsche Forschungsgemeinschaft | - |
Descrição: dc.description | Institute of Anatomy and Cell Biology Justus-Liebig-University Giessen | - |
Descrição: dc.description | Hessian Centre of Reproductive Medicine Justus-Liebig-University Giessen | - |
Descrição: dc.description | Department of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Urology Pediatric Urology and Andrology University Hospital Justus-Liebig-University Giessen | - |
Descrição: dc.description | Department of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University (UNESP) | - |
Descrição: dc.description | Deutsche Forschungsgemeinschaft: BH 93/1-4 | - |
Descrição: dc.description | Deutsche Forschungsgemeinschaft: GRK 1871/2 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Frontiers in Immunology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | bacterial infection | - |
Palavras-chave: dc.subject | epididymis | - |
Palavras-chave: dc.subject | epididymitis | - |
Palavras-chave: dc.subject | infertility | - |
Palavras-chave: dc.subject | mononuclear phagocytes | - |
Palavras-chave: dc.subject | uropathogenic E. coli | - |
Título: dc.title | Differential Immune Response to Infection and Acute Inflammation Along the Epididymis | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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