Anticontractile Effect of Perivascular Adipose Tissue But Not of Endothelium Is Enhanced by Hydrogen Sulfide Stimulation in Hypertensive Pregnant Rat Aortae

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSouza-Paula, Edileia [UNESP]-
Autor(es): dc.creatorPolonio, Leticia C C-
Autor(es): dc.creatorZochio, Gabriela P.-
Autor(es): dc.creatorda Silva, Katiussia Pinho-
Autor(es): dc.creatorKushima, Helio-
Autor(es): dc.creatorDias-Junior, Carlos A.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:47Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/FJC.0000000000000917-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206970-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206970-
Descrição: dc.descriptionPerivascular adipose tissue (PVAT) modulates the vascular tone. Hydrogen sulfide (H2S) is synthetized by cystathionine gamma-lyase (CSE) in brown PVAT. Modulation of vascular contractility by H2S is, in part, adenosine triphosphate (ATP)-sensitive potassium channels dependent. However, the role of PVAT-derived H2S in hypertensive pregnancy (HTN-Preg) is unclear. Therefore, we aimed to examine the involvement of H2S in the anticontractile effect of PVAT in aortae from normotensive and hypertensive pregnant rats. To this end, phenylephrine-induced contractions in the presence and absence of PVAT and endothelium in aortae from normotensive pregnant (Norm-Preg) and HTN-Preg rats were investigated. Maternal blood pressure, fetal-placental parameters, angiogenesis-related biomarkers, and H2S levels were also assessed. We found that circulating H2S is elevated in hypertensive pregnancy associated with angiogenic imbalance, fetal and placental growth restrictions, which revealed that there is H2S pathway activation. Moreover, under stimulated H2S formation PVAT, but not endothelium, reduced phenylephrine-induced contractions in aortae from HTN-Preg rats. Also, H2S synthesis inhibitor abolished anticontractile effects of PVAT and endothelium. Furthermore, anticontractile effect of PVAT, but not of endothelium, was eliminated by ATP-sensitive potassium channels blocker. In accordance, increases in H2S levels in PVAT and placenta, but not in aortae without PVAT, were also observed. In conclusion, anticontractile effect of PVAT is lost, at least in part, in HTN-Preg aortae and PVAT effect is ATP-sensitive potassium channels dependent in normotensive and hypertensive pregnant rat aortae. PVAT but not endothelium is responsive to the H2S stimulation in hypertensive pregnant rat aortae, implying a key role for PVAT-derived H2S under endothelial dysfunction.-
Descrição: dc.descriptionDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP)-
Formato: dc.format715-729-
Idioma: dc.languageen-
Relação: dc.relationJournal of cardiovascular pharmacology-
???dc.source???: dc.sourceScopus-
Título: dc.titleAnticontractile Effect of Perivascular Adipose Tissue But Not of Endothelium Is Enhanced by Hydrogen Sulfide Stimulation in Hypertensive Pregnant Rat Aortae-
Tipo de arquivo: dc.typelivro digital-
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