Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorMomesso, Gustavo Antonio Correa [UNESP]-
Autor(es): dc.creatorPolo, Tarik Ocon Braga [UNESP]-
Autor(es): dc.creatorda Silva, William Phillip Pereira [UNESP]-
Autor(es): dc.creatorBarbosa, Stéfany [UNESP]-
Autor(es): dc.creatorFreitas, Gileade P.-
Autor(es): dc.creatorLopes, Helena Bacha-
Autor(es): dc.creatorRosa, Adalberto Luiz-
Autor(es): dc.creatorCordeiro, Jairo Matozinho-
Autor(es): dc.creatorToro, Luan Felipe [UNESP]-
Autor(es): dc.creatorChiba, Fernando Yamamoto [UNESP]-
Autor(es): dc.creatorMatsushita, Doris Hissako [UNESP]-
Autor(es): dc.creatorLouzada, Mario Jefferson Quirino [UNESP]-
Autor(es): dc.creatorda Cruz, Nilson Cristino [UNESP]-
Autor(es): dc.creatorBarão, Valentim A.R.-
Autor(es): dc.creatorFaverani, Leonardo P. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:46Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.msec.2020.111775-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206966-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206966-
Descrição: dc.descriptionThe treatment of polytrauma patients represents a great challenge in the maxillofacial and orthopedic surgery fields. Therefore, this study tested the hypothesis that the use of a bioactive coating (by plasma electrolytic oxidation, PEO) on titanium microplates could improve the fracture healing of low bone mineral density (BMD) rats. Thirty female rats underwent bilateral ovariectomy surgery (OVX), and 35 rats underwent fake surgery (SHAM). Three months later, animals were subjected to femoral fracture simulation and were fixed with either non-coated (CONV) or coated (PEO) titanium miniplates. Eight weeks postoperatively, microplate/bone complexes were analyzed through computed microtomography, histometric, confocal microscopy, molecular, and biomechanical analysis. Bioactive elements (Ca and P) were incorporated on the PEO microplate and the surface was modified in a volcano-like structure. In the microCT analysis the OVX/PEO group had greater values for Tb.Th (bone trabecular thickness), Tb.Sp (separation of bone trabeculae) and Tb.N (number of trabeculae) parameters compared to the OVX/CONV group. According to histometric analysis, the OVX/PEO group showed significantly higher new bone formation than the OVX/CONV group (P < 0.05). For the fluorochrome area, the OVX groups (PEO and CONV) showed greater values for calcein precipitation (old bone) than alizarin red (new bone). Molecular results showed greater values for proteins related to the final phase of bone formation (P < 0.05) in the OVX/PEO group. The OVX/PEO group showed higher bone/miniplate system resilience compared to the others (P < 0.05). It was concluded that PEO coating optimizes bone healing on simulated femoral fractures in low bone mineral density rats. This sheds new light in the treatment of osteoporotic patients with bone fractures.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionBone Res Lab School of Dentistry of Ribeirao Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP)-
Descrição: dc.descriptionInstituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP)-
Descrição: dc.descriptionDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionInstituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista: 01.12.0530.00-FINEP/PROINFRA 01/2011-
Descrição: dc.descriptionFAPESP: 2016/20297-6-
Descrição: dc.descriptionFAPESP: 2018/00522-0-
Idioma: dc.languageen-
Relação: dc.relationMaterials Science and Engineering C-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiochemical markers of bone turnover-
Palavras-chave: dc.subjectBone histomorphometry-
Palavras-chave: dc.subjectOsteoporosis-
Palavras-chave: dc.subjectPreclinical studies-
Título: dc.titleMiniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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