Poly-ε-caprolactone nanoparticles loaded with 4-nerolidylcatechol (4-nc) for growth inhibition of microsporum canis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorLauro de Souza Lima Institute-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorUniversity of Chile-
Autor(es): dc.contributorAdvanced Center for Chronic Diseases-
Autor(es): dc.creatorGreatti, Vanessa Raquel [UNESP]-
Autor(es): dc.creatorOda, Fernando [UNESP]-
Autor(es): dc.creatorSorrechia, Rodrigo [UNESP]-
Autor(es): dc.creatorKapp, Bárbara Regina [UNESP]-
Autor(es): dc.creatorSeraphim, Carolina Manzato [UNESP]-
Autor(es): dc.creatorWeckwerth, Ana Carolina Villas Bôas-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorDa Silva, Patrícia Bento [UNESP]-
Autor(es): dc.creatorEloy, Josimar O.-
Autor(es): dc.creatorKogan, Marcelo J.-
Autor(es): dc.creatorMorales, Javier O.-
Autor(es): dc.creatorRodrigues Pietro, Rosemeire Cristina Linhari [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:46Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics9120894-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206965-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206965-
Descrição: dc.descriptionDermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound’s stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara-Jaú, Km 1-
Descrição: dc.descriptionDepartment of Mycology Lauro de Souza Lima Institute-
Descrição: dc.descriptionDepartment of Pharmacy School of Pharmacy Dentistry and Nursing Federal University of Ceará, University Avenue, 2853 Rodolfo Teófilo-
Descrição: dc.descriptionSchool of Chemical and Pharmaceutical Sciences University of Chile, Santos Dumont 964, Independencia-
Descrição: dc.descriptionAdvanced Center for Chronic Diseases, Sergio Livingstone 1007-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara-Jaú, Km 1-
Descrição: dc.descriptionFAPESP: 2016/02107-5-
Formato: dc.format1-16-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject4-Nerolidylcatechol-
Palavras-chave: dc.subjectAntifungals-
Palavras-chave: dc.subjectMicrosporum canis-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectNanoprecipitation-
Palavras-chave: dc.subjectPolycaprolactone-
Título: dc.titlePoly-ε-caprolactone nanoparticles loaded with 4-nerolidylcatechol (4-nc) for growth inhibition of microsporum canis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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