Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorKm 235-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorAlmeida, Vitor Y. G.-
Autor(es): dc.creatorRocha, Josias S.-
Autor(es): dc.creatorFelix, Débora P.-
Autor(es): dc.creatorOliveira, Gabriela P.-
Autor(es): dc.creatorLima, Mauro A.-
Autor(es): dc.creatorFarias, Renan L. [UNESP]-
Autor(es): dc.creatorZanetti, Renan D. [UNESP]-
Autor(es): dc.creatorNetto, Adelino V. G. [UNESP]-
Autor(es): dc.creatorZambom, Carolina R. [UNESP]-
Autor(es): dc.creatorGarrido, Saulo S. [UNESP]-
Autor(es): dc.creatorRocha, Fillipe V.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:43Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:43Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/slct.202004093-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206948-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206948-
Descrição: dc.descriptionThe present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compounds were synthesized and characterized by NMR 1H, 13C-{1H}, 31P, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionChemistry Department Federal University of São Carlos Rod. Washington Luis Km 235-
Descrição: dc.descriptionDepartment of Analytical Chemistry Physicochemical and Inorganic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55-
Descrição: dc.descriptionDepartment of Analytical Chemistry Physicochemical and Inorganic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55-
Descrição: dc.descriptionFAPESP: 2018/03018-1-
Descrição: dc.descriptionFAPESP: 2019/17584-1-
Descrição: dc.descriptionFAPESP: FAPESP 2019/11242-1-
Formato: dc.format14559-14563-
Idioma: dc.languageen-
Relação: dc.relationChemistrySelect-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibacterial-
Palavras-chave: dc.subjectAntiproliferation-
Palavras-chave: dc.subjectDNA interaction-
Palavras-chave: dc.subjectNMR spectroscopy-
Palavras-chave: dc.subjectSilver (I)-
Título: dc.titleCytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.