Telocytes contribute to aging-related modifications in the prostate

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSanches, Bruno Domingos Azevedo-
Autor(es): dc.creatorTamarindo, Guilherme Henrique-
Autor(es): dc.creatordos Santos Maldarine, Juliana-
Autor(es): dc.creatorda Silva, Alana Della Torre [UNESP]-
Autor(es): dc.creatordos Santos, Vitória Alário [UNESP]-
Autor(es): dc.creatorLima, Maria Letícia Duarte [UNESP]-
Autor(es): dc.creatorRahal, Paula [UNESP]-
Autor(es): dc.creatorGóes, Rejane Maira [UNESP]-
Autor(es): dc.creatorTaboga, Sebastião Roberto [UNESP]-
Autor(es): dc.creatorFelisbino, Sérgio Luis [UNESP]-
Autor(es): dc.creatorCarvalho, Hernandes F.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-78532-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206936-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206936-
Descrição: dc.descriptionTelocytes are interstitial cells present in the stroma of several organs, including the prostate. There is evidence that these cells are present during prostate alveologenesis, in which these cells play a relevant role, but there is no information about the presence of and possible changes in telocytes during prostate aging. Throughout aging, the prostate undergoes several spontaneous changes in the stroma that are pro-pathogenic. Our study used histochemistry, 3D reconstructions, ultrastructure and immunofluorescence to compare the adult prostate with the senile prostate of the Mongolian gerbil, in order to investigate possible changes in telocytes with senescence and a possible role for these cells in the age-associated alterations. It was found that the layers of perialveolar smooth muscle become thinner as the prostatic alveoli become more dilated during aging, and that telocytes form a network that involves smooth muscle cells, which could possibly indicate a role for telocytes in maintaining the integrity of perialveolar smooth muscles. On the other hand, with senescence, VEGF+ telocytes are seen in stroma possibly contributing to angiogenesis, together with TNFR1+ telocytes, which are associated with a pro-inflammatory microenvironment in the prostate. Together, these data indicate that telocytes are important both in understanding the aging-related changes that are seen in the prostate and also in the search for new therapeutic targets for pathologies whose frequency increases with age.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), Bertrand Russel Av.-
Descrição: dc.descriptionLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265-
Descrição: dc.descriptionLaboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265-
Descrição: dc.descriptionLaboratory of Extracellular Matrix Institute of Biosciences São Paulo State University – UNESP, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District-
Descrição: dc.descriptionLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265-
Descrição: dc.descriptionLaboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265-
Descrição: dc.descriptionLaboratory of Extracellular Matrix Institute of Biosciences São Paulo State University – UNESP, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District-
Descrição: dc.descriptionFAPESP: 2018/08945-8-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleTelocytes contribute to aging-related modifications in the prostate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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