Leukotriene B4 licenses inflammasome activation to enhance skin host defense

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Autor(es): dc.contributorVanderbilt University Medical Center-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorIndiana University School of Medicine-
Autor(es): dc.contributorFIOCRUZ-
Autor(es): dc.creatorSalina, Ana Carolina Guerta [UNESP]-
Autor(es): dc.creatorBrandt, Stephanie L.-
Autor(es): dc.creatorKlopfenstein, Nathan-
Autor(es): dc.creatorBlackman, Amondrea-
Autor(es): dc.creatorBazzano, Júlia Miranda Ribeiro-
Autor(es): dc.creatorSá-Nunes, Anderson-
Autor(es): dc.creatorByers-Glosson, Nicole-
Autor(es): dc.creatorBrodskyn, Claudia-
Autor(es): dc.creatorTavares, Natalia Machado-
Autor(es): dc.creatorSilva, Icaro Bonyek Santos Da-
Autor(es): dc.creatorMedeiros, Alexandra I. [UNESP]-
Autor(es): dc.creatorHenrique Serezani, C.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:40Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1073/pnas.2002732117-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206930-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206930-
Descrição: dc.descriptionThe initial production of inflammatory mediators dictates host defense as well as tissue injury. Inflammasome activation is a constituent of the inflammatory response by recognizing pathogen and host-derived products and eliciting the production of IL-1β and IL-18 in addition to inducing a type of inflammatory cell death termed “pyroptosis.” Leukotriene B4 (LTB4) is a lipid mediator produced quickly (seconds to minutes) by phagocytes and induces chemotaxis, increases cytokine/chemokine production, and enhances antimicrobial effector functions. Whether LTB4 directly activates the inflammasome remains to be determined. Our data show that endogenously produced LTB4 is required for the expression of pro-IL-1β and enhances inflammasome assembly in vivo and in vitro. Furthermore, LTB4-mediated Bruton’s tyrosine kinase (BTK) activation is required for inflammasome assembly in vivo as well for IL-1β–enhanced skin host defense. Together, these data unveil a new role for LTB4 in enhancing the expression and assembly of inflammasome components and suggest that while blocking LTB4 actions could be a promising therapeutic strategy to prevent inflammasome-mediated diseases, exogenous LTB4 can be used as an adjuvant to boost inflammasome-dependent host defense.-
Descrição: dc.descriptionDepartment of Medicine Division of Infectious Diseases Vanderbilt University Medical Center-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Faculty of Medicine of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Indiana University School of Medicine-
Descrição: dc.descriptionVanderbilt Institute of Infection Immunology and Inflammation Vanderbilt University Medical Center-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionOswaldo Cruz Foundation Gonçalo Moniz Institute FIOCRUZ-
Descrição: dc.descriptionDepartment of Pathology Microbiology and Immunology Vanderbilt University Medical Center-
Descrição: dc.descriptionVanderbilt Center for Immunobiology Vanderbilt University Medical Center-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format30619-30627-
Idioma: dc.languageen-
Relação: dc.relationProceedings of the National Academy of Sciences of the United States of America-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInflammasome | leukotriene | skin | innate immunity-
Título: dc.titleLeukotriene B4 licenses inflammasome activation to enhance skin host defense-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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