A Comparative Meta-Analysis and in silico Analysis of Differentially Expressed Genes and Proteins in Canine and Human Bladder Cancer

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorHarvard University-
Autor(es): dc.contributorUniversità degli Studi di Milano-
Autor(es): dc.contributorPaulista University—UNIP-
Autor(es): dc.creatorVitti Gambim, Victoria [UNESP]-
Autor(es): dc.creatorLaufer-Amorim, Renee [UNESP]-
Autor(es): dc.creatorFonseca Alves, Ricardo Henrique-
Autor(es): dc.creatorGrieco, Valeria-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:35Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fvets.2020.558978-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206902-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206902-
Descrição: dc.descriptionCanine and human bladder cancer present similar anatomical, morphological, and molecular characteristics, and dogs can be considered a model for human bladder cancer. However, the veterinary literature lacks information regarding cross-validation analysis between human and canine large-scale data. Therefore, this research aimed to perform a meta-analysis of the canine literature on bladder cancer, identifying genes and proteins previously evaluated in these studies. In addition, we also performed a cross-validation of the canine transcriptome data and the human data from The Cancer Genome Atlas (TCGA) to identify potential markers for both species. The meta-analysis was performed using the following indexing terms: “bladder” AND “carcinoma” AND “dog” in different international databases, and 385 manuscripts were identified in our initial search. Then, several inclusion criteria were applied, and only 25 studies met these criteria. Among these studies, five presented transcriptome data, and 20 evaluated only isolated genes or proteins. Regarding the studies involving isolated protein analysis, the HER-2 protein was the most studied (3/20), followed by TAG-72 (2/20), COX-2 (2/20), survivin (2/20), and CK7 (2/20), and the remaining nine studies evaluated one isolated protein each. Regarding the cross-validation analysis of human and canine transcriptome data, we identified 35 dysregulated genes, including ERBB2, TP53, EGFR, and E2F2. Our results demonstrate that the canine literature on bladder cancer previously focused on the evaluation of isolated markers with no association with patient survival. This limitation may be related to the lack of a homogenous protocol for treating patients and the lack of follow-up during treatment. In addition, the lack of information regarding tumor muscle invasion can be considered an important limitation when comparing human and canine bladder tumors. Our in silico analysis involving canine and human transcriptome data provided several genes with the potential to be markers for both human and canine bladder tumors, and these genes should be considered for future studies on canine bladder cancer.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionJohn A Paulson School of Engineering and Applied Sciences Harvard University-
Descrição: dc.descriptionDepartment of Veterinary Medicine Università degli Studi di Milano-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University—UNIP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcomparative oncology-
Palavras-chave: dc.subjectdog-
Palavras-chave: dc.subjectgene ontology-
Palavras-chave: dc.subjecttransitional cell carcinoma-
Palavras-chave: dc.subjecttyrosine kinase-
Título: dc.titleA Comparative Meta-Analysis and in silico Analysis of Differentially Expressed Genes and Proteins in Canine and Human Bladder Cancer-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.