Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Silva, Débora E. S. [UNESP] | - |
Autor(es): dc.creator | Becceneri, Amanda B. | - |
Autor(es): dc.creator | Santiago, João V. B. [UNESP] | - |
Autor(es): dc.creator | Gomes Neto, José A. [UNESP] | - |
Autor(es): dc.creator | Ellena, Javier | - |
Autor(es): dc.creator | Cominetti, Márcia R. | - |
Autor(es): dc.creator | Pereira, José C. M. [UNESP] | - |
Autor(es): dc.creator | Hannon, Michael J. | - |
Autor(es): dc.creator | Netto, Adelino V. G. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:48:33Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:48:33Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-06 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1039/d0dt01134g | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206895 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206895 | - |
Descrição: dc.description | Novel silver(i) complexes of the type [AgCl(PPh3)2(L)] {PPh3 = triphenylphosphine; L = VTSC = 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazone (1); VMTSC = 3-methoxy-4-[2-(morpholine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (2); VPTSC = 3-methoxy-4-[2-(piperidine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (3)} were synthesized and fully characterized by spectroscopic techniques. The molecular structures of complexes 2 and 3 were determined by single crystal X-ray diffraction. Compounds 1-3 exhibited appreciable cytotoxic activity against human tumor cells (lung A549, breast MDA-MB-231 and MCF-7) with IC50 values in 48 h of incubation ranging from 5.6 to 18 μM. Cellular uptake studies showed that complexes 1-3 were efficiently internalized after 3 hours of treatment in MDA-MB-231 cells. The effects of complex 1 on the cell morphology, cell cycle, induction of apoptosis, mitochondrial membrane potential (Δψm), and reactive oxygen species (ROS) production have been evaluated in triple negative breast cancer (TNBC) cells MDA-MB-231. Our results showed that complex 1 induced typical morphological alterations of cell death, an increase in cells at the sub-G1 phase, apoptosis, and mitochondrial membrane depolarization. Furthermore, DNA binding studies evidenced that 1 can bind to ct-DNA and does so without modifying the B-structure of the DNA, but that the binding is weak compared to that of Hoechst 33258. | - |
Descrição: dc.description | Department of General and Inorganic Chemistry Department of Analytical Chemistry UNESP-São Paulo State University Institute of Chemistry | - |
Descrição: dc.description | Department de Gerontology Federal University of São Carlos | - |
Descrição: dc.description | São Carlos Institute of Physics University of São Paulo | - |
Descrição: dc.description | School of Chemistry University of Birmingham | - |
Descrição: dc.description | Department of General and Inorganic Chemistry Department of Analytical Chemistry UNESP-São Paulo State University Institute of Chemistry | - |
Formato: dc.format | 16474-16487 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Dalton Transactions | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Silver(i) complexes of 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazones and triphenylphosphine: structural, cytotoxicity, and apoptotic studies | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: