Silver(i) complexes of 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazones and triphenylphosphine: structural, cytotoxicity, and apoptotic studies

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSilva, Débora E. S. [UNESP]-
Autor(es): dc.creatorBecceneri, Amanda B.-
Autor(es): dc.creatorSantiago, João V. B. [UNESP]-
Autor(es): dc.creatorGomes Neto, José A. [UNESP]-
Autor(es): dc.creatorEllena, Javier-
Autor(es): dc.creatorCominetti, Márcia R.-
Autor(es): dc.creatorPereira, José C. M. [UNESP]-
Autor(es): dc.creatorHannon, Michael J.-
Autor(es): dc.creatorNetto, Adelino V. G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:33Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d0dt01134g-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206895-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206895-
Descrição: dc.descriptionNovel silver(i) complexes of the type [AgCl(PPh3)2(L)] {PPh3 = triphenylphosphine; L = VTSC = 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazone (1); VMTSC = 3-methoxy-4-[2-(morpholine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (2); VPTSC = 3-methoxy-4-[2-(piperidine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (3)} were synthesized and fully characterized by spectroscopic techniques. The molecular structures of complexes 2 and 3 were determined by single crystal X-ray diffraction. Compounds 1-3 exhibited appreciable cytotoxic activity against human tumor cells (lung A549, breast MDA-MB-231 and MCF-7) with IC50 values in 48 h of incubation ranging from 5.6 to 18 μM. Cellular uptake studies showed that complexes 1-3 were efficiently internalized after 3 hours of treatment in MDA-MB-231 cells. The effects of complex 1 on the cell morphology, cell cycle, induction of apoptosis, mitochondrial membrane potential (Δψm), and reactive oxygen species (ROS) production have been evaluated in triple negative breast cancer (TNBC) cells MDA-MB-231. Our results showed that complex 1 induced typical morphological alterations of cell death, an increase in cells at the sub-G1 phase, apoptosis, and mitochondrial membrane depolarization. Furthermore, DNA binding studies evidenced that 1 can bind to ct-DNA and does so without modifying the B-structure of the DNA, but that the binding is weak compared to that of Hoechst 33258.-
Descrição: dc.descriptionDepartment of General and Inorganic Chemistry Department of Analytical Chemistry UNESP-São Paulo State University Institute of Chemistry-
Descrição: dc.descriptionDepartment de Gerontology Federal University of São Carlos-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo-
Descrição: dc.descriptionSchool of Chemistry University of Birmingham-
Descrição: dc.descriptionDepartment of General and Inorganic Chemistry Department of Analytical Chemistry UNESP-São Paulo State University Institute of Chemistry-
Formato: dc.format16474-16487-
Idioma: dc.languageen-
Relação: dc.relationDalton Transactions-
???dc.source???: dc.sourceScopus-
Título: dc.titleSilver(i) complexes of 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazones and triphenylphosphine: structural, cytotoxicity, and apoptotic studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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