Evaluation of the prognostic potential of EGFL7 in pilocytic astrocytomas

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorDr. Paulo Prata – FACISB-
Autor(es): dc.contributorThe Ohio State University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorICVS/3B's – PT Government Associate Laboratory-
Autor(es): dc.creatorBrunhara, Bruno B.-
Autor(es): dc.creatorBecker, Aline P.-
Autor(es): dc.creatorNeder, Luciano-
Autor(es): dc.creatorGonçalves, Paola G. [UNESP]-
Autor(es): dc.creatorde Oliveira, Cristiane [UNESP]-
Autor(es): dc.creatorClara, Carlos A.-
Autor(es): dc.creatorReis, Rui M.-
Autor(es): dc.creatorBidinotto, Lucas T. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:32Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/neup.12698-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206887-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206887-
Descrição: dc.descriptionPilocytic astrocytoma (PA) is the most frequent solid neoplasm in childhood. It has a good 5-year overall survival (90% in childhood and 52% in adults). However, up to 20% of patients experience residual tumor growth, recurrence, and death. Although the main genetic alteration of PAs, including KIAA1549:BRAF fusion, involves chromosome 7q34, we previously found frequent loss in chr9q34.3 locus in a small subset of these tumors. Among the genes present in this locus, EGFL7 is related to poor prognosis in several tumor types. In this study, we aimed to assess EGFL7 expression through immunohistochemistry, and to evaluate its prognostic value in a series of 64 clinically and molecularly well-characterized pilocytic astrocytomas. We found high expression of EGFL7 in 71.9% of patients. Low EGFL7 expression was associated with older patients, the mean age mainly older than 11 years (P = 0.027). EGFL7 expression was not associated with presence of KIAA1549:BRAF fusion, BRAF mutation, FGFR1 mutation, nor FGFR1 duplication. Moreover, high EGFL7 expression was associated with high FGFR1 (P = 0.037) and 5′-deoxy-5′-methyltioadenosine phosphorylase (MTAP) (P = 0.005) expression, and with unfavorable outcome of patients (P = 0.047). Multivariate analysis revealed low EGFL7 expression related to older patients and high EGFL7 expression related to retained expression of MTAP. In addition, we found a borderline significance of unfavorable outcome and high EGFL7 expression. Finally, EGFL7 expression was not associated with overall or event-free survival of PA patients. Our findings point to EGFL7 expression as a novel candidate prognostic marker in PA, which should be further investigated.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital-
Descrição: dc.descriptionBarretos School of Health Sciences Dr. Paulo Prata – FACISB-
Descrição: dc.descriptionDepartment of Radiation Oncology The Ohio State University-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Neurosurgery Barretos Cancer Hospital-
Descrição: dc.descriptionLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho-
Descrição: dc.descriptionICVS/3B's – PT Government Associate Laboratory-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University-UNESP-
Descrição: dc.descriptionFAPESP: 2012/19590-0-
Descrição: dc.descriptionFAPESP: 2016/21727-4-
Descrição: dc.descriptionFAPESP: 2016/23919-8-
Descrição: dc.descriptionFAPESP: 2017/09749-5-
Descrição: dc.descriptionCNPq: 472447/2013-0-
Formato: dc.format21-28-
Idioma: dc.languageen-
Relação: dc.relationNeuropathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEGFL7-
Palavras-chave: dc.subjectFGFR1-
Palavras-chave: dc.subjectimmunohistochemistry-
Palavras-chave: dc.subjectMTAP-
Palavras-chave: dc.subjectpilocytic astrocytoma-
Título: dc.titleEvaluation of the prognostic potential of EGFL7 in pilocytic astrocytomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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