Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorOeste Paulista University – UNOESTE-
Autor(es): dc.creatorZamame Ramirez, Jofer Andree [UNESP]-
Autor(es): dc.creatorRomagnoli, Graziela Gorete [UNESP]-
Autor(es): dc.creatorKaneno, Ramon [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:26Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2020.118745-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206855-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206855-
Descrição: dc.descriptionCytotoxic drugs remain the first-line option for cancer therapy but the development of drug-resistance by tumor cells represents a primary obstacle for successful chemotherapy. Autophagy is a physiological mechanism of cell survival efficiently used by tumor cells to avoid cell death and to induce drug-resistance. It is a macromolecular process, in which cells degrade and recycle intracellular substrates and damaged organelles to alleviate cell stress caused by nutritional deprivation, hypoxia, irradiation, and cytotoxic agents, as well. There is evidence that autophagy prevents cancer during the early steps of carcinogenesis, but once transformed, these cells show enhanced autophagy capacity and use it to survive, grow, and facilitate metastasis. Current basic studies and clinical trials show the feasibility of using pharmacological or molecular blockage of autophagy to improve the anticancer therapy efficiency. In this review, we overviewed the pathways and molecular aspects of autophagy, its role in carcinogenesis, and the evidence for its role in cancer adaptation and drug-resistance. Finally, we reviewed the clinical findings on how the autophagy interference helps to improve conventional anticancer therapy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University – UNESP Department of Chemical and Biological Sciences Institute of Biosciences of Botucatu-
Descrição: dc.descriptionSão Paulo State University – UNESP Department of Pathology School of Medicine of Botucatu-
Descrição: dc.descriptionOeste Paulista University – UNOESTE Department of Health Sciences-
Descrição: dc.descriptionSão Paulo State University – UNESP Department of Chemical and Biological Sciences Institute of Biosciences of Botucatu-
Descrição: dc.descriptionSão Paulo State University – UNESP Department of Pathology School of Medicine of Botucatu-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutophagy-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectChemoresistance-
Palavras-chave: dc.subjectChemotherapy-
Palavras-chave: dc.subjectTumor escape-
Título: dc.titleInhibiting autophagy to prevent drug resistance and improve anti-tumor therapy-
Aparece nas coleções:Repositório Institucional - Unesp

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