Plasma and Peritoneal Ceftriaxone Concentrations After Intraperitoneal Administration in Horses With Septic Peritonitis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorAlonso, Juliana de M. [UNESP]-
Autor(es): dc.creatorMartins, Evelin S. [UNESP]-
Autor(es): dc.creatorPeccinini, Rosangela G. [UNESP]-
Autor(es): dc.creatorRosa, Gustavo S. [UNESP]-
Autor(es): dc.creatorGuerra, Simony T. [UNESP]-
Autor(es): dc.creatorRibeiro, Márcio G. [UNESP]-
Autor(es): dc.creatorSantos, Bruna [UNESP]-
Autor(es): dc.creatorGarcía, Henry D.M. [UNESP]-
Autor(es): dc.creatorWatanabe, Marcos J. [UNESP]-
Autor(es): dc.creatorTakahira, Regina K. [UNESP]-
Autor(es): dc.creatorRodrigues, Celso A. [UNESP]-
Autor(es): dc.creatorAlves, Ana Liz G. [UNESP]-
Autor(es): dc.creatorHussni, Carlos A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jevs.2020.103310-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206819-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206819-
Descrição: dc.descriptionIntraperitoneal ceftriaxone administration in healthy horses results in high and prolonged peritoneal concentrations. Recent findings suggest that intraperitoneal ceftriaxone might increase survival rates in horses affected by peritonitis. The present study aimed to evaluate plasma and peritoneal concentrations of ceftriaxone after intraperitoneal administration in horses with septic peritonitis. Twenty-six horses presenting clinical, laboratorial, and sonographic findings compatible with the disease were included. All horses received daily intraperitoneal ceftriaxone (25 mg/kg bwt) in addition or not with other antibiotics and support therapies. High-performance liquid chromatography was used to determine plasma and peritoneal ceftriaxone concentrations before and after 12 and 24 hours of ceftriaxone administration. Mean plasma concentrations 12 and 24 hours after administration were, respectively, 1.84 ± 0.43 and 0.37 ± 0.07 μg/mL, and mean peritoneal concentrations were 5.7 ± 2.84 and 0.42 ± 0.13 μg/mL. Ceftriaxone concentration was lower in comparison with previous studies in healthy horses and presented under the minimal inhibitory concentration for enterobacteria (≤1 μg/mL) and for gram-positive isolates (≤0.5 μg/mL) at 24 hours. The variation of the results obtained between healthy horses and with septic peritonitis demonstrated that pharmacokinetics/dynamics are different between these patients and suggests the use of an interval of dose of 12 hours.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)-
Descrição: dc.descriptionFAPESP: # 2016/08713-8-
Idioma: dc.languageen-
Relação: dc.relationJournal of Equine Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAbdominal infection-
Palavras-chave: dc.subjectHPLC-
Palavras-chave: dc.subjectMIC-
Palavras-chave: dc.subjectPeritoneum-
Título: dc.titlePlasma and Peritoneal Ceftriaxone Concentrations After Intraperitoneal Administration in Horses With Septic Peritonitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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