Influence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats

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Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCarvalho, Marianna R.-
Autor(es): dc.creatorMendonça, Maria Lua M.-
Autor(es): dc.creatorOliveira, Jéssica M.L.-
Autor(es): dc.creatorRomanenghi, Rodrigo B.-
Autor(es): dc.creatorMorais, Camila S.-
Autor(es): dc.creatorOta, Gabriel E.-
Autor(es): dc.creatorLima, Aline R.R. [UNESP]-
Autor(es): dc.creatorOliveira, Rodrigo J.-
Autor(es): dc.creatorFiliú, Wander F.O.-
Autor(es): dc.creatorOkoshi, Katashi [UNESP]-
Autor(es): dc.creatorOkoshi, Marina P. [UNESP]-
Autor(es): dc.creatorOliveira-Junior, Silvio A.-
Autor(es): dc.creatorMartinez, Paula F.-
Data de aceite: dc.date.accessioned2022-02-22T00:48:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:16Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2020.118697-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206794-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206794-
Descrição: dc.descriptionAim: To evaluate the influence of intermittent fasting and high-intensity interval training (HIIT) on myocardial apoptosis signaling and cardiac morphological characteristics in healthy rats. Methods: Male Wistar rats (n = 60) were divided into four groups: sedentary control (SED-C), intermittent fasting (SED-IF), high-intensity interval training (HIIT-C), and high-intensity interval training plus intermittent fasting (HIIT-IF). SED-C and HIIT-C groups were treated daily with ad libitum chow; SED-IF and HIIT-IF received the same standard chow every other day. HIIT-C and HIIT-IF rats were submitted to an HIIT protocol five times a week for 12 weeks. At the end of the experiment, functional capacity, cardiac morphology, and expression of apoptosis signaling pathways-related proteins were analyzed. Key findings: HIIT increased cardiomyocyte cross-sectional area, collagen interstitial fraction, and the pro-apoptotic proteins AIF and caspase-3 expression, and reduced pro-apoptotic protein CYTC expression and the cleaved-to-non-cleaved PARP-1 ratio in myocardium. Intermittent fasting reduced cardiomyocyte cross-sectional area, collagen interstitial fraction, and expression of Bax, CYTC and cleaved PARP-1, and increased expression of the anti-apoptotic protein BCL-2. SMAC, ARC, and caspase-8 expression was not changed by HIIT or intermittent fasting. Significance: HIIT promotes cardiomyocyte hypertrophy and interstitial fibrosis, and modulates the apoptosis signaling pathway in healthy rat myocardium. Intermittent fasting reduces pro-apoptotic and increases antiapoptotic signaling, besides attenuating HIIT-induced cardiomyocyte hypertrophy and myocardial interstitial fibrosis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionStriated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS)-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 482556/2013-7-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectHeart-
Palavras-chave: dc.subjectPhysical exercise-
Palavras-chave: dc.subjectTime restricted feeding-
Título: dc.titleInfluence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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