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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Federal de Mato Grosso do Sul (UFMS) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Carvalho, Marianna R. | - |
Autor(es): dc.creator | Mendonça, Maria Lua M. | - |
Autor(es): dc.creator | Oliveira, Jéssica M.L. | - |
Autor(es): dc.creator | Romanenghi, Rodrigo B. | - |
Autor(es): dc.creator | Morais, Camila S. | - |
Autor(es): dc.creator | Ota, Gabriel E. | - |
Autor(es): dc.creator | Lima, Aline R.R. [UNESP] | - |
Autor(es): dc.creator | Oliveira, Rodrigo J. | - |
Autor(es): dc.creator | Filiú, Wander F.O. | - |
Autor(es): dc.creator | Okoshi, Katashi [UNESP] | - |
Autor(es): dc.creator | Okoshi, Marina P. [UNESP] | - |
Autor(es): dc.creator | Oliveira-Junior, Silvio A. | - |
Autor(es): dc.creator | Martinez, Paula F. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:48:16Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:48:16Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.lfs.2020.118697 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206794 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206794 | - |
Descrição: dc.description | Aim: To evaluate the influence of intermittent fasting and high-intensity interval training (HIIT) on myocardial apoptosis signaling and cardiac morphological characteristics in healthy rats. Methods: Male Wistar rats (n = 60) were divided into four groups: sedentary control (SED-C), intermittent fasting (SED-IF), high-intensity interval training (HIIT-C), and high-intensity interval training plus intermittent fasting (HIIT-IF). SED-C and HIIT-C groups were treated daily with ad libitum chow; SED-IF and HIIT-IF received the same standard chow every other day. HIIT-C and HIIT-IF rats were submitted to an HIIT protocol five times a week for 12 weeks. At the end of the experiment, functional capacity, cardiac morphology, and expression of apoptosis signaling pathways-related proteins were analyzed. Key findings: HIIT increased cardiomyocyte cross-sectional area, collagen interstitial fraction, and the pro-apoptotic proteins AIF and caspase-3 expression, and reduced pro-apoptotic protein CYTC expression and the cleaved-to-non-cleaved PARP-1 ratio in myocardium. Intermittent fasting reduced cardiomyocyte cross-sectional area, collagen interstitial fraction, and expression of Bax, CYTC and cleaved PARP-1, and increased expression of the anti-apoptotic protein BCL-2. SMAC, ARC, and caspase-8 expression was not changed by HIIT or intermittent fasting. Significance: HIIT promotes cardiomyocyte hypertrophy and interstitial fibrosis, and modulates the apoptosis signaling pathway in healthy rat myocardium. Intermittent fasting reduces pro-apoptotic and increases antiapoptotic signaling, besides attenuating HIIT-induced cardiomyocyte hypertrophy and myocardial interstitial fibrosis. | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
Descrição: dc.description | Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) | - |
Descrição: dc.description | Internal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Internal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP) | - |
Descrição: dc.description | CAPES: 001 | - |
Descrição: dc.description | CNPq: 482556/2013-7 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Life Sciences | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Apoptosis | - |
Palavras-chave: dc.subject | Heart | - |
Palavras-chave: dc.subject | Physical exercise | - |
Palavras-chave: dc.subject | Time restricted feeding | - |
Título: dc.title | Influence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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