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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | University of Michigan School of Public Health | - |
Autor(es): dc.contributor | Universidade de Guarulhos - UNG | - |
Autor(es): dc.creator | Pérez-Pacheco, Cindy Grace [UNESP] | - |
Autor(es): dc.creator | Fernandes, Natalie Ap. Rodrigues [UNESP] | - |
Autor(es): dc.creator | Primo, Fernando Lucas [UNESP] | - |
Autor(es): dc.creator | Tedesco, Antonio Claudio | - |
Autor(es): dc.creator | Bellile, Emily | - |
Autor(es): dc.creator | Retamal-Valdes, Belen | - |
Autor(es): dc.creator | Feres, Magda | - |
Autor(es): dc.creator | Guimarães-Stabili, Morgana Rodrigues [UNESP] | - |
Autor(es): dc.creator | Rossa, Carlos [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:48:03Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:48:03Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-05-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1007/s00784-020-03652-3 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206763 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206763 | - |
Descrição: dc.description | Objective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy. | - |
Descrição: dc.description | Department of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao Paulo | - |
Descrição: dc.description | Biostatistics University of Michigan School of Public Health | - |
Descrição: dc.description | Department of Periodontology and Oral Implantology Dental Research Division Universidade de Guarulhos - UNG | - |
Descrição: dc.description | Department of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP) | - |
Formato: dc.format | 3217-3227 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Clinical Oral Investigations | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Curcumin | - |
Palavras-chave: dc.subject | Dental Scaling | - |
Palavras-chave: dc.subject | Nanoparticles | - |
Palavras-chave: dc.subject | Periodontitis | - |
Título: dc.title | Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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