Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Michigan School of Public Health-
Autor(es): dc.contributorUniversidade de Guarulhos - UNG-
Autor(es): dc.creatorPérez-Pacheco, Cindy Grace [UNESP]-
Autor(es): dc.creatorFernandes, Natalie Ap. Rodrigues [UNESP]-
Autor(es): dc.creatorPrimo, Fernando Lucas [UNESP]-
Autor(es): dc.creatorTedesco, Antonio Claudio-
Autor(es): dc.creatorBellile, Emily-
Autor(es): dc.creatorRetamal-Valdes, Belen-
Autor(es): dc.creatorFeres, Magda-
Autor(es): dc.creatorGuimarães-Stabili, Morgana Rodrigues [UNESP]-
Autor(es): dc.creatorRossa, Carlos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:48:03Z-
Data de disponibilização: dc.date.available2022-02-22T00:48:03Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03652-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206763-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206763-
Descrição: dc.descriptionObjective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao Paulo-
Descrição: dc.descriptionBiostatistics University of Michigan School of Public Health-
Descrição: dc.descriptionDepartment of Periodontology and Oral Implantology Dental Research Division Universidade de Guarulhos - UNG-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP)-
Formato: dc.format3217-3227-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCurcumin-
Palavras-chave: dc.subjectDental Scaling-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectPeriodontitis-
Título: dc.titleLocal application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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