The pathophysiology of rett syndrome with a focus on breathing dysfunctions

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Washington School of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAnn & Robert H. Lurie Children’s Hospital of Chicago-
Autor(es): dc.contributorNorthwestern University Feinberg School of Medicine-
Autor(es): dc.creatorRamirez, Jan-Marino-
Autor(es): dc.creatorKarlen-Amarante, Marlusa [UNESP]-
Autor(es): dc.creatorWang, Jia-Der Ju-
Autor(es): dc.creatorBush, Nicholas E.-
Autor(es): dc.creatorCarroll, Michael S.-
Autor(es): dc.creatorWeese-Mayer, Debra E.-
Autor(es): dc.creatorHuff, Alyssa-
Data de aceite: dc.date.accessioned2022-02-22T00:47:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/physiol.00008.2020-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206700-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206700-
Descrição: dc.descriptionRett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrelated disturbances in the genetic and homeostatic regulation of central and peripheral neuronal networks, redox state, and control of inflammation. Characteristic breath-holds, obstructive sleep apnea, and aerophagia result in intermittent hypoxia, which, combined with mitochondrial dysfunction, causes oxidative stress-an important driver of the clinical presentation of RTT.-
Descrição: dc.descriptionCenter for Integrative Brain Research Seattle Children’s Research Institute University of Washington School of Medicine-
Descrição: dc.descriptionDepartments of Neurological Surgery and Pediatrics University of Washington School of Medicine-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry of Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionAnn & Robert H. Lurie Children’s Hospital of Chicago-
Descrição: dc.descriptionDepartment of Pediatrics Northwestern University Feinberg School of Medicine-
Descrição: dc.descriptionDivision of Autonomic Medicine Ann & Robert H. Lurie Children’s Hospital of Chicago-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry of Araraquara São Paulo State University (UNESP)-
Formato: dc.format375-390-
Idioma: dc.languageen-
Relação: dc.relationPhysiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutonomic dysregulation-
Palavras-chave: dc.subjectBreathing-
Palavras-chave: dc.subjectDysphagia-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleThe pathophysiology of rett syndrome with a focus on breathing dysfunctions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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