RNA-sequencing of the Nyssomyia neivai sialome: a sand fly-vector from a Brazilian endemic area for tegumentary leishmaniasis and pemphigus foliaceus

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorNational Institutes of Health (NIH)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorVernal, Sebastian-
Autor(es): dc.creatorOliveira, Fabiano-
Autor(es): dc.creatorOliveira, Wanderson H. C. [UNESP]-
Autor(es): dc.creatorGoulart, Thais M. [UNESP]-
Autor(es): dc.creatorOristian, James-
Autor(es): dc.creatorCalvo, Eric-
Autor(es): dc.creatorPinto, Mara C. [UNESP]-
Autor(es): dc.creatorRoselino, Ana Maria-
Autor(es): dc.creatorRibeiro, José M. C.-
Data de aceite: dc.date.accessioned2022-02-22T00:47:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:53Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-74343-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206696-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206696-
Descrição: dc.descriptionLeishmaniasis encompasses a spectrum of diseases caused by a protozoan belonging to the genus Leishmania. The parasite is transmitted by the bite of sand flies, which inoculate the promastigote forms into the host’s skin while acquiring a blood meal. Nyssomyia neivai is one of the main vectors of tegumentary leishmaniasis (TL) in Brazil. Southeastern Brazil is an endemic region for TL but also overlaps with an endemic focus for pemphigus foliaceus (PF), also known as Fogo Selvagem. Salivary proteins of sand flies, specifically maxadilan and LJM11, have been related to pemphigus etiopathogenesis in the New World, being proposed as an environmental trigger for autoimmunity. We present a comprehensive description of the salivary transcriptome of the N. neivai, using deep sequencing achieved by the Illumina protocol. In addition, we highlight the abundances of several N. neivai salivary proteins and use phylogenetic analysis to compare with Old- and New-World sand fly salivary proteins. The collection of protein sequences associated with the salivary glands of N. neivai can be useful for monitoring vector control strategies as biomarkers of N. neivai, as well as driving vector-vaccine design for leishmaniasis. Additionally, this catalog will serve as reference to screen for possible antigenic peptide candidates triggering anti-Desmoglein-1 autoantibodies.-
Descrição: dc.descriptionDivision of Intramural Research, National Institute of Allergy and Infectious Diseases-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDivision of Dermatology Department of Clinical Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionLaboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health (NIH)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Infectious Diseases University of São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleRNA-sequencing of the Nyssomyia neivai sialome: a sand fly-vector from a Brazilian endemic area for tegumentary leishmaniasis and pemphigus foliaceus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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