Efficacy and safety of glucose, glucose and polidocanol combination, liquid polidocanol and polidocanol foam in the treatment of reticular veins: A randomized study in rabbits

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorHistopathologie und VascPath-
Autor(es): dc.creatorLucio Filho, Carlos Eduardo Pinheiro [UNESP]-
Autor(es): dc.creatorBertanha, Matheus [UNESP]-
Autor(es): dc.creatorPrata, Marcela Polachini [UNESP]-
Autor(es): dc.creatorCarvalho, Lídia Raquel de [UNESP]-
Autor(es): dc.creatorJaldin, Rodrigo Gibin [UNESP]-
Autor(es): dc.creatorSobreira, Marcone Lima [UNESP]-
Autor(es): dc.creatorJanzen, Jan [UNESP]-
Autor(es): dc.creatorYoshida, Winston Bonetti [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/0268355520964293-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206630-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206630-
Descrição: dc.descriptionObjective: To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears. Methods: Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol-glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy (luminal occlusion), complications (phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology (sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis). Results: Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis (p = 0.003), 46.15% ulceration (p = 0.003), and 69.2% local inflammation (p < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis (p = 0.03) in the foam group. Conclusions: Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events.-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP-
Descrição: dc.descriptionDepartment of Biostatistics-Biosciences Institute Paulista State University UNESP-
Descrição: dc.descriptionHistopathologie und VascPath-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP-
Descrição: dc.descriptionDepartment of Biostatistics-Biosciences Institute Paulista State University UNESP-
Formato: dc.format303-312-
Idioma: dc.languageen-
Relação: dc.relationPhlebology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanimal models-
Palavras-chave: dc.subjectefficacy-
Palavras-chave: dc.subjectsafety-
Palavras-chave: dc.subjectsclerosing solutions-
Palavras-chave: dc.subjectsclerotherapy-
Palavras-chave: dc.subjectVaricose veins-
Título: dc.titleEfficacy and safety of glucose, glucose and polidocanol combination, liquid polidocanol and polidocanol foam in the treatment of reticular veins: A randomized study in rabbits-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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