Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorNorthwestern University-
Autor(es): dc.contributorUniversity of Ribeirão Preto—UNAERP-
Autor(es): dc.creatorGonçalves, Francyenne Maira Castro [UNESP]-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo [UNESP]-
Autor(es): dc.creatorGomes, Leonardo Fernandes-
Autor(es): dc.creatorEmerenciano, Nayara Gonçalves [UNESP]-
Autor(es): dc.creatordos Passos Silva, Matheus [UNESP]-
Autor(es): dc.creatorCannon, Mark L.-
Autor(es): dc.creatorDanelon, Marcelle [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:32Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03597-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206580-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206580-
Descrição: dc.descriptionObjective: To evaluate the effect of treatment with fluoridated toothpaste supplemented with a combination of sodium trimetaphosphate (TMP) and casein phosphopeptide-amorphous calcium phosphate (MI Paste Plus®) on the demineralization of dental enamel. Methods: Bovine enamel blocks selected by initial surface hardness (SHi) were randomly allocated into six groups (n = 12), according to the test toothpastes: (1) without F-TMP-MI Paste Plus® (Placebo); (2) 1100 ppm F (1100F); (3) MI Paste Plus®; (4) 1100F + MI Paste Plus® (1100F-MI Paste Plus), (5) 1100F + 3 % TMP (1100F-TMP); and (6) 1100F-TMP + MI Paste Plus® (1100F-TMP-MI Paste Plus). Blocks were treated two times per day with slurries of toothpaste (1 min), and groups 4 and 6 received an application of MI Paste Plus (3 min). Next, the samples were subjected to five pH cycles (demineralizing/remineralizing solutions) at 37 °C, to produce subsurface enamel lesions.Thereafter, the blocks were maintained for 2 days in fresh remineralizing solution. After pH cycling, the following were obtained: percentage of surface hardness loss (%SH); integrated loss of subsurface hardness (ΔKHN); profile analysis and lesion depth subsurface through polarized light microscopy (PLM); scanning electron microscopy (SEM); and fluoride (F), calcium (Ca), and phosphorus (P) in the enamel. The data were subjected to ANOVA (1-criterion), followed by the Student–Newman–Keuls test (p < 0.001). Results: The 1100F-TMP-MI Paste Plus group showed better results for SHR, ΔKHN, and PLM (p < 0.001). The F concentration was similar among all groups (p > 0.001). The 1100F-TMP-MI Paste Plus group showed the highest concentration of Ca and P in the enamel (p < 0.001). Conclusion: The application of 1100F-TMP-MI Paste Plus promoted a higher inhibitory effect against enamel demineralization. Clinical significance: The combination of treatments with F, TMP, and MI Paste Plus® can be an effective alternative to improve the oral health of individuals, especially those with high activity of dental caries and at high risk for its development.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry Araçatuba, Rua José Bonifácio 1193-
Descrição: dc.descriptionDepartment of Materials Engineering Federal University of São Carlos - UFSCar-
Descrição: dc.descriptionFeinberg School of Medicine Ann and Robert Lurie Children’s Hospital Northwestern University-
Descrição: dc.descriptionSchool of Dentistry University of Ribeirão Preto—UNAERP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry Araçatuba, Rua José Bonifácio 1193-
Formato: dc.format2811-2820-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCPP-ACPF-
Palavras-chave: dc.subjectDemineralization-
Palavras-chave: dc.subjectDental enamel-
Palavras-chave: dc.subjectFluoride-
Palavras-chave: dc.subjectPhosphate-
Título: dc.titleCombined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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