HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFAMERP-
Autor(es): dc.creatorNogueira, Rodrigo L.-
Autor(es): dc.creatorKüpper, Daniel S.-
Autor(es): dc.creatordo Bonfim, Caroline M. [UNESP]-
Autor(es): dc.creatorAragon, Davi C.-
Autor(es): dc.creatorDamico, Thiago A.-
Autor(es): dc.creatorMiura, Carolina S.-
Autor(es): dc.creatorPassos, Ivna M.-
Autor(es): dc.creatorNogueira, Maurício L.-
Autor(es): dc.creatorRahal, Paula [UNESP]-
Autor(es): dc.creatorValera, Fabiana C. P.-
Data de aceite: dc.date.accessioned2022-02-22T00:47:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:25Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/coa.13640-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206542-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206542-
Descrição: dc.descriptionObjectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)-
Descrição: dc.descriptionDepartment of Pediatrics Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Research in Virology School of Medicine of São José do Rio Preto FAMERP-
Descrição: dc.descriptionDepartment of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)-
Descrição: dc.descriptionFAPESP: 10/00029-0-
Descrição: dc.descriptionFAPESP: CNPq-
Formato: dc.format181-188-
Idioma: dc.languageen-
Relação: dc.relationClinical Otolaryngology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthuman papillomavirus-
Palavras-chave: dc.subjectoutcome-
Palavras-chave: dc.subjectrecurrent respiratory papillomatosis-
Palavras-chave: dc.subjectsurgery-
Palavras-chave: dc.subjecttype-
Palavras-chave: dc.subjectvariant-
Título: dc.titleHPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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