Analysis of RPL37A, MTSS1, and HTRA1 expression as potential markers for pathologic complete response and survival

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorHospital de Câncer de Barretos-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCarrara, Guilherme Freire Angotti-
Autor(es): dc.creatorEvangelista, Adriane Feijo-
Autor(es): dc.creatorScapulatempo-Neto, Cristovam-
Autor(es): dc.creatorAbrahão-Machado, Lucas Faria-
Autor(es): dc.creatorMorini, Mariana Andozia-
Autor(es): dc.creatorKerr, Ligia Maria-
Autor(es): dc.creatorFolgueira, Maria Aparecida Azevedo Koike-
Autor(es): dc.creatorda Costa Vieira, René Aloisio [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12282-020-01159-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206525-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206525-
Descrição: dc.descriptionBackground: Non-metastatic locally advanced breast carcinoma (LABC) treatment involves neoadjuvant chemotherapy (NCT). We evaluated the association of clinical–pathological data and immunoexpression of hormone receptors, HER2 and Ki67, and new biomarkers, RPL37A, MTSS1 and HTRA1, with pathological complete response (PCR) or tumour resistance (stable disease or disease progression), disease-free survival (DFS) and cancer-specific survival (CSS). Methods: This is a retrospective study of 333 patients with LABC who underwent NCT. Expression of MTSS1, RPL37A and HTRA1/PRSS11 was evaluated by immunohistochemistry in TMA slides. Cutoff values were established for low and high tumour expression. ROC plotter evaluated response to NCT. Chi-square test for factors related to PCR, and Kaplan–Meier test and Cox model for factors related to DFS and CSS were prformed. Results: The mean follow-up was 70.0 months and PCR rate was 15.6%. At 120 months, DFS rate was 32.5% and CSS rate was 67.1%. In multivariate analysis, there was an association between: (1) necrosis presence, intense inflammatory infiltrate, ER absence, HER2 molecular subtype and high RPL3A expression with increased odds of PCR; (2) lymph node involvement (LNI), high Ki67, low RPL37A and high HTRA1 expression with increased risk for NCT non-response; (3) LNI, high proliferation, necrosis absence, low RPL37A and high HTRA1 expression with increased recurrence risk; (4) advanced LNI, ER negative tumours, high HTRA1, low RPL37A expression and desmoplasia presence with higher risk of cancer death. Conclusion: RPL37A is a potential biomarker for response to NCT and for prognosis. Additional studies evaluating HTRA1 and MTSS1 prognostic value are needed.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Oncologia Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331, Bairro Dr Paulo Prata-
Descrição: dc.descriptionCentro de Pesquisa Molecular em Oncologia Hospital de Câncer de Barretos-
Descrição: dc.descriptionDepartamento de Patologia Hospital de Câncer de Barretos-
Descrição: dc.descriptionPrograma de Pós-Graduação em Oncologia Departamento de Radiologia e Oncologia Faculdade de Medicina FMUSP Universidade de São Paulo FMUSP-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ginecologia Obstetricia e Mastologia Faculdade de Medicina de Botucatu/UNESP-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ginecologia Obstetricia e Mastologia Faculdade de Medicina de Botucatu/UNESP-
Descrição: dc.descriptionFAPESP: 2012/19642-0-
Formato: dc.format307-320-
Idioma: dc.languageen-
Relação: dc.relationBreast Cancer-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers, tumor-
Palavras-chave: dc.subjectBreast neoplasms-
Palavras-chave: dc.subjectNeoadjuvant therapy-
Palavras-chave: dc.subjectPathologic complete response-
Palavras-chave: dc.subjectSurvival analysis-
Título: dc.titleAnalysis of RPL37A, MTSS1, and HTRA1 expression as potential markers for pathologic complete response and survival-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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