Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorForgerini, Marcela [UNESP]-
Autor(es): dc.creatorLucchetta, Rosa Camila [UNESP]-
Autor(es): dc.creatorUrbano, Gustavo-
Autor(es): dc.creatorde Nadai, Tales Rubens-
Autor(es): dc.creatorde Carvalho Mastroianni, Patrícia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41397-020-00185-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206523-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206523-
Descrição: dc.descriptionNon-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB. Twenty-one publications and 7134 participants were included. Thirteen studies evaluated genetic polymorphism in patients exposed to non-steroidal anti-inflammatory drugs, low-dose aspirin, and warfarin. Eight studies present at least one methodological problem. Only six studies clearly defined that the outcome evaluated was non-variceal UGIB. Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1; COX-2; PLA2G7; GP1BA; GRS; IL1RN; F13A1; CDKN2B-AS1; DPP6; TBXA2R; TNF-alpha; VKORC1; CYP2C9; and AGT). Further well-designed studies are needed (e.g., clear restriction to non-variceal UGIB; proper selection of participants; and adjustment of confounding factors) to provide strong evidence for pharmacogenetic and personalized medicine.-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Surgery School of Medicine University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Public Health Bauru School of Dentistry University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format20-36-
Idioma: dc.languageen-
Relação: dc.relationPharmacogenomics Journal-
???dc.source???: dc.sourceScopus-
Título: dc.titleGenetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review-
Aparece nas coleções:Repositório Institucional - Unesp

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