Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorJorge, Bárbara Campos [UNESP]-
Autor(es): dc.creatorReis, Ana Carolina Casali [UNESP]-
Autor(es): dc.creatorSterde, Érika Tissiana [UNESP]-
Autor(es): dc.creatorBalin, Paola da Silva [UNESP]-
Autor(es): dc.creatorScarano, Wellerson Rodrigo [UNESP]-
Autor(es): dc.creatorHisano, Hamilton-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:18Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2020.128016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206500-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206500-
Descrição: dc.descriptionBenzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 μg/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary. Prepubertal BaP-exposure compromised reproductive parameters in male rats, causing permanent changes in StAR protein expression in testis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionEmbrapa Environment-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionFAPESP: 2017/22176-4-
Descrição: dc.descriptionFAPESP: 2019/03284-6-
Idioma: dc.languageen-
Relação: dc.relationChemosphere-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocrine disruptor-
Palavras-chave: dc.subjectPolycyclic aromatic hydrocarbons-
Palavras-chave: dc.subjectStAR protein-
Palavras-chave: dc.subjectTestosterone levels-
Título: dc.titleExposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.