In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFreitas, Jolindo A. [UNESP]-
Autor(es): dc.creatorSorrechia, Rodrigo [UNESP]-
Autor(es): dc.creatorPoliti, Flávio A. S. [UNESP]-
Autor(es): dc.creatorSantos, André G. [UNESP]-
Autor(es): dc.creatorRodrigues, Edvânio R. [UNESP]-
Autor(es): dc.creatorSantos, Lourdes C. [UNESP]-
Autor(es): dc.creatorFusco-Almeida, Ana M. [UNESP]-
Autor(es): dc.creatorOliveira, Andrew A.-
Autor(es): dc.creatorGuido, Rafael V. C.-
Autor(es): dc.creatorPietro, Rosemeire C. L. R. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:17Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:17Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2019.1569656-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206494-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206494-
Descrição: dc.descriptionDermatophytosis is a dermic disease caused by fungi. The aim of this study was to search anti-dermatophyte bioactive compounds in Piper umbellatum leaves. Cytotoxicity evaluation was performed against MRC-5 and HepG2 as a selectivity parameter. Crude ethanol extract presented MIC value of 39.1 μg/mL against M. canis and no cytotoxicity to Hep G2 (human liver cancer) and MRC-5 (normal lung fibroblast). 4-nerolydilcatechol was isolated from P. umbellatum ethanolic extract. MIC values for 4-NC were 7.6μM to M. canisand 15.6μM to Trichophyton rubrum. 4-NC presented activity against M. canis14 times lower than to MRC-5 (non-tumoral human cell line), which suggest selective activity for this fungus. Molecular modeling suggests 4-NC could bind to CYP51, present in lanosterol synthesis, blocking fungi development. In conclusion, P. umbellatum crude ethanol extract and 4-NC demonstrated high and selective in vitro antifungal activity. (Figure presented.).-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Drugs and Medicines São Paulo State University(UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Natural Principles and Toxicology São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry Department of Organic Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University(UNESP)-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo (USP)-
Descrição: dc.descriptionJolindo A. Freitas School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Drugs and Medicines São Paulo State University(UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Natural Principles and Toxicology São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry Department of Organic Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University(UNESP)-
Formato: dc.format3423-3427-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject4-Nerolidylcatechol-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectdermatophytes;Piper umbellatum-
Título: dc.titleIn vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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