Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorUniversity of Sorocaba-
Autor(es): dc.contributorSorocaba Technology Park-
Autor(es): dc.creatorD'Angelo, Natália A.-
Autor(es): dc.creatorNoronha, Mariana A.-
Autor(es): dc.creatorKurnik, Isabelle S. [UNESP]-
Autor(es): dc.creatorCâmara, Mayra C.C.-
Autor(es): dc.creatorVieira, Jorge M.-
Autor(es): dc.creatorAbrunhosa, Luís-
Autor(es): dc.creatorMartins, Joana T.-
Autor(es): dc.creatorAlves, Thais F.R.-
Autor(es): dc.creatorTundisi, Louise L.-
Autor(es): dc.creatorAtaide, Janaína A.-
Autor(es): dc.creatorCosta, Juliana S.R.-
Autor(es): dc.creatorJozala, Angela F.-
Autor(es): dc.creatorNascimento, Laura O.-
Autor(es): dc.creatorMazzola, Priscila G.-
Autor(es): dc.creatorChaud, Marco V.-
Autor(es): dc.creatorVicente, António A.-
Autor(es): dc.creatorLopes, André M.-
Data de aceite: dc.date.accessioned2022-02-22T00:47:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-07-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2021.120534-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206480-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206480-
Descrição: dc.descriptionCurcumin (CUR) is a phenolic compound present in some herbs, including Curcuma longa Linn. (turmeric rhizome), with a high bioactive capacity and characteristic yellow color. It is mainly used as a spice, although it has been found that CUR has interesting pharmaceutical properties, acting as a natural antioxidant, anti-inflammatory, antimicrobial, and antitumoral agent. Nonetheless, CUR is a hydrophobic compound with low water solubility, poor chemical stability, and fast metabolism, limiting its use as a pharmacological compound. Smart drug delivery systems (DDS) have been used to overcome its low bioavailability and improve its stability. The current work overviews the literature from the past 10 years on the encapsulation of CUR in nanostructured systems, such as micelles, liposomes, niosomes, nanoemulsions, hydrogels, and nanocomplexes, emphasizing its use and ability in cancer therapy. The studies highlighted in this review have shown that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCentre of Biological Engineering (CEB) University of Minho-
Descrição: dc.descriptionLaboratory of Biomaterials and Nanotechnology (LaBNUS) University of Sorocaba-
Descrição: dc.descriptionCollege of Engineering of Bioprocess and Biotechnology University of Sorocaba-
Descrição: dc.descriptionSorocaba Development and Innovation Agency (INOVA Sorocaba) Sorocaba Technology Park-
Descrição: dc.descriptionLaboratory of Industrial Microbiology and Fermentation Process (LAMINFE) University of Sorocaba-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioactive encapsulation-
Palavras-chave: dc.subjectCancer therapy-
Palavras-chave: dc.subjectCurcumin (CUR)-
Palavras-chave: dc.subjectDrug delivery systems (DDS)-
Palavras-chave: dc.subjectNanostructures-
Palavras-chave: dc.subjectNanotechnology-
Título: dc.titleCurcumin encapsulation in nanostructures for cancer therapy: A 10-year overview-
Aparece nas coleções:Repositório Institucional - Unesp

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