Nose-to-brain co-delivery of drugs for glioblastoma treatment using nanostructured system

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorICVS/3B's-PT Government Associate Laboratory-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.creatorFerreira, Natália N. [UNESP]-
Autor(es): dc.creatorde Oliveira Junior, Edilson-
Autor(es): dc.creatorGranja, Sara-
Autor(es): dc.creatorBoni, Fernanda I. [UNESP]-
Autor(es): dc.creatorFerreira, Leonardo M.B. [UNESP]-
Autor(es): dc.creatorCury, Beatriz S.F. [UNESP]-
Autor(es): dc.creatorSantos, Lilian C.R.-
Autor(es): dc.creatorReis, Rui M.-
Autor(es): dc.creatorLima, Eliana M.-
Autor(es): dc.creatorBaltazar, Fátima-
Autor(es): dc.creatorGremião, Maria Palmira D. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:47:02Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:02Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2021.120714-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206415-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206415-
Descrição: dc.descriptionMutations on the epidermal growth factor receptor (EGFR), induction of angiogenesis, and reprogramming cellular energetics are all biological features acquired by tumor cells during tumor development, and also known as the hallmarks of cancer. Targeted therapies that combine drugs that are capable of acting against such concepts are of great interest, since they can potentially improve the therapeutic efficacy of treatments of complex pathologies, such as glioblastoma (GBM). However, the anatomical location and biological behavior of this neoplasm imposes great challenges for targeted therapies. A novel strategy that combines alpha-cyano-4-hydroxycinnamic acid (CHC) with the monoclonal antibody cetuximab (CTX), both carried onto a nanotechnology-based delivery system, is herein proposed for GBM treatment via nose-to-brain delivery. The biological performance of Poly (D,L-lactic-co-glycolic acid)/chitosan nanoparticles (NP), loaded with CHC, and conjugated with CTX by covalent bonds (conjugated NP) were extensively investigated. The NP platforms were able to control CHC release, indicating that drug release was driven by the Weibull model. An ex vivo study with nasal porcine mucosa demonstrated the capability of these systems to promote CHC and CTX permeation. Blot analysis confirmed that CTX, covalently associated to NP, impairs EGRF activation. The chicken chorioallantoic membrane assay demonstrated a trend of tumor reduction when conjugated NP were employed. Finally, images acquired by fluorescence tomography evidenced that the developed nanoplatform was effective in enabling nose-to-brain transport upon nasal administration. In conclusion, the developed delivery system exhibited suitability as an effective novel co-delivery approaches for GBM treatment upon intranasal administration.-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University UNESP, Rodovia Araraquara/Jaú Km 01-
Descrição: dc.descriptionLaboratório de Nanotecnologia Farmacêutica e Sistemas de Liberação de Fármacos FarmaTec Faculdade de Farmácia Universidade Federal de Goiás - UFG, 5ª Avenida c/Rua 240 s/n, Praça Universitária-
Descrição: dc.descriptionLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho-
Descrição: dc.descriptionICVS/3B's-PT Government Associate Laboratory-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University UNESP, Rodovia Araraquara/Jaú Km 01-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCetuximab-
Palavras-chave: dc.subjectGlioblastoma-
Palavras-chave: dc.subjectHallmarks of cancer-
Palavras-chave: dc.subjectNanotechnology-
Palavras-chave: dc.subjectNose-to-brain delivery-
Palavras-chave: dc.subjectα-Cyano-4-hydroxycinnamic acid-
Título: dc.titleNose-to-brain co-delivery of drugs for glioblastoma treatment using nanostructured system-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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