Reactivation of multiple fetal mirnas in lung adenocarcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBritish Columbia Cancer Research Centre-
Autor(es): dc.contributorA.C. Camargo Cancer Center-
Autor(es): dc.contributorNYU Langone Medical Center-
Autor(es): dc.contributorBritish Columbia Children’s Hospital Research Institute-
Autor(es): dc.contributorUniversity of British Columbia-
Autor(es): dc.contributorUniversity Health Network-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCohn, David E.-
Autor(es): dc.creatorBarros-Filho, Mateus C.-
Autor(es): dc.creatorMinatel, Brenda C.-
Autor(es): dc.creatorPewarchuk, Michelle E.-
Autor(es): dc.creatorMarshall, Erin A.-
Autor(es): dc.creatorVucic, Emily A.-
Autor(es): dc.creatorSage, Adam P.-
Autor(es): dc.creatorTelkar, Nikita-
Autor(es): dc.creatorStewart, Greg L.-
Autor(es): dc.creatorJurisica, Igor-
Autor(es): dc.creatorReis, Patricia P. [UNESP]-
Autor(es): dc.creatorRobinson, Wendy P.-
Autor(es): dc.creatorLam, Wan L.-
Data de aceite: dc.date.accessioned2022-02-22T00:47:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:47:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers13112686-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206405-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206405-
Descrição: dc.descriptionMicroRNAs (miRNAs) play vital roles in the regulation of normal developmental pathways. However, cancer cells can co-opt these miRNAs, and the pathways that they regulate, to drive pro-tumourigenic phenotypes. Characterization of the miRNA transcriptomes of fetal organs is essential for identifying these oncofetal miRNAs, but it has been limited by fetal sample availability. As oncofetal miRNAs are absent from healthy adult lungs, they represent ideal targets for developing diagnostic and therapeutic strategies. We conducted small RNA sequencing of a rare collection of 25 human fetal lung (FL) samples and compared them to two independent cohorts (n = 140, n = 427), each comprised of adult non-neoplastic lung (ANL) and lung adenocarcinoma (LUAD) samples. We identified 13 oncofetal miRNAs that were expressed in FL and LUAD but not in ANL. These oncofetal miRNAs are potential biomarkers for LUAD detection (AUC = 0.963). Five of these miRNAs are derived from the imprinted C14MC miRNA cluster at the 14q32 locus, which has been associated with cancer development and abnormal fetal and placental development. Additionally, we observed the pulmonary expression of 44 previously unannotated miRNAs. The sequencing of these fetal lung samples also provides a baseline resource against which aberrant samples can be compared.-
Descrição: dc.descriptionKrembil Foundation-
Descrição: dc.descriptionCanada Foundation for Innovation-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada-
Descrição: dc.descriptionCanadian Institutes of Health Research-
Descrição: dc.descriptionBritish Columbia Cancer Research Centre-
Descrição: dc.descriptionInternational Research Center A.C. Camargo Cancer Center-
Descrição: dc.descriptionNYU Langone Medical Center-
Descrição: dc.descriptionBritish Columbia Children’s Hospital Research Institute-
Descrição: dc.descriptionDepartment of Medical Genetics University of British Columbia-
Descrição: dc.descriptionDivision of Orthopedic Surgery Schroeder Arthritis Institute University Health Network-
Descrição: dc.descriptionData Science Discovery Centre for Chronic Diseases Krembil Research Institute University Health Network-
Descrição: dc.descriptionDepartment of Medical Biophysics University of Toronto-
Descrição: dc.descriptionDepartment of Computer Science University of Toronto-
Descrição: dc.descriptionFaculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionCanada Foundation for Innovation: 203373-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada: 203475-
Descrição: dc.descriptionCanada Foundation for Innovation: 30865-
Descrição: dc.descriptionCanadian Institutes of Health Research: FDN-143345-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLung adenocarcinoma-
Palavras-chave: dc.subjectMicroRNA-
Palavras-chave: dc.subjectNovel microRNA-
Palavras-chave: dc.subjectOncofetal-
Título: dc.titleReactivation of multiple fetal mirnas in lung adenocarcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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