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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | British Columbia Cancer Research Centre | - |
Autor(es): dc.contributor | A.C. Camargo Cancer Center | - |
Autor(es): dc.contributor | NYU Langone Medical Center | - |
Autor(es): dc.contributor | British Columbia Children’s Hospital Research Institute | - |
Autor(es): dc.contributor | University of British Columbia | - |
Autor(es): dc.contributor | University Health Network | - |
Autor(es): dc.contributor | University of Toronto | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Cohn, David E. | - |
Autor(es): dc.creator | Barros-Filho, Mateus C. | - |
Autor(es): dc.creator | Minatel, Brenda C. | - |
Autor(es): dc.creator | Pewarchuk, Michelle E. | - |
Autor(es): dc.creator | Marshall, Erin A. | - |
Autor(es): dc.creator | Vucic, Emily A. | - |
Autor(es): dc.creator | Sage, Adam P. | - |
Autor(es): dc.creator | Telkar, Nikita | - |
Autor(es): dc.creator | Stewart, Greg L. | - |
Autor(es): dc.creator | Jurisica, Igor | - |
Autor(es): dc.creator | Reis, Patricia P. [UNESP] | - |
Autor(es): dc.creator | Robinson, Wendy P. | - |
Autor(es): dc.creator | Lam, Wan L. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:47:00Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:47:00Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/cancers13112686 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206405 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206405 | - |
Descrição: dc.description | MicroRNAs (miRNAs) play vital roles in the regulation of normal developmental pathways. However, cancer cells can co-opt these miRNAs, and the pathways that they regulate, to drive pro-tumourigenic phenotypes. Characterization of the miRNA transcriptomes of fetal organs is essential for identifying these oncofetal miRNAs, but it has been limited by fetal sample availability. As oncofetal miRNAs are absent from healthy adult lungs, they represent ideal targets for developing diagnostic and therapeutic strategies. We conducted small RNA sequencing of a rare collection of 25 human fetal lung (FL) samples and compared them to two independent cohorts (n = 140, n = 427), each comprised of adult non-neoplastic lung (ANL) and lung adenocarcinoma (LUAD) samples. We identified 13 oncofetal miRNAs that were expressed in FL and LUAD but not in ANL. These oncofetal miRNAs are potential biomarkers for LUAD detection (AUC = 0.963). Five of these miRNAs are derived from the imprinted C14MC miRNA cluster at the 14q32 locus, which has been associated with cancer development and abnormal fetal and placental development. Additionally, we observed the pulmonary expression of 44 previously unannotated miRNAs. The sequencing of these fetal lung samples also provides a baseline resource against which aberrant samples can be compared. | - |
Descrição: dc.description | Krembil Foundation | - |
Descrição: dc.description | Canada Foundation for Innovation | - |
Descrição: dc.description | Natural Sciences and Engineering Research Council of Canada | - |
Descrição: dc.description | Canadian Institutes of Health Research | - |
Descrição: dc.description | British Columbia Cancer Research Centre | - |
Descrição: dc.description | International Research Center A.C. Camargo Cancer Center | - |
Descrição: dc.description | NYU Langone Medical Center | - |
Descrição: dc.description | British Columbia Children’s Hospital Research Institute | - |
Descrição: dc.description | Department of Medical Genetics University of British Columbia | - |
Descrição: dc.description | Division of Orthopedic Surgery Schroeder Arthritis Institute University Health Network | - |
Descrição: dc.description | Data Science Discovery Centre for Chronic Diseases Krembil Research Institute University Health Network | - |
Descrição: dc.description | Department of Medical Biophysics University of Toronto | - |
Descrição: dc.description | Department of Computer Science University of Toronto | - |
Descrição: dc.description | Faculty of Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | Faculty of Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | Canada Foundation for Innovation: 203373 | - |
Descrição: dc.description | Natural Sciences and Engineering Research Council of Canada: 203475 | - |
Descrição: dc.description | Canada Foundation for Innovation: 30865 | - |
Descrição: dc.description | Canadian Institutes of Health Research: FDN-143345 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Cancers | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Lung adenocarcinoma | - |
Palavras-chave: dc.subject | MicroRNA | - |
Palavras-chave: dc.subject | Novel microRNA | - |
Palavras-chave: dc.subject | Oncofetal | - |
Título: dc.title | Reactivation of multiple fetal mirnas in lung adenocarcinoma | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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