The protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Campos, Thaís Dantis Pereira-
Autor(es): dc.creatorda Cruz Rodrigues, Kellen Cristina-
Autor(es): dc.creatorPereira, Rodrigo Martins-
Autor(es): dc.creatorAnaruma, Chadi Pellegrini-
Autor(es): dc.creatordos Santos Canciglieri, Raphael-
Autor(es): dc.creatorde Melo, Diego Gomes-
Autor(es): dc.creatorda Silva, Adelino Sanchez Ramos-
Autor(es): dc.creatorCintra, Dennys Esper-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorPauli, José Rodrigo-
Autor(es): dc.creatorde Moura, Leandro Pereira [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:58Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:58Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11033-021-06419-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206391-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206391-
Descrição: dc.descriptionObesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health. This disorder has been pointed out as leading to the development of a diversity of eye diseases and, consequently, damage to visual acuity. More specifically, cardiometabolic risk is associated with lacrimal gland dysfunctions, since it changes the inflammatory profile favoring the development and worsening of dry eye disease. In more severe and extreme cases, obesity, inflammation, and diabetes mellitus type 2 can trigger the total loss of vision. In this scenario, besides its numerous metabolic functions, clusterin, an apolipoprotein, has been described as protective to the ocular surface through the seal mechanism. Thus, the current review aimed to explain the role of clusterin in dry eye disease that can be triggered by obesity and diabetes.-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas, 1300 Pedro Zaccaria Street-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionLaboratory of Nutritional Genomics (LABGeN) School of Applied Sciences University of Campinas-
Descrição: dc.descriptionCEPECE - Center of Research in Sport Sciences. School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionPostgraduate Program in Motricity Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionPostgraduate Program in Motricity Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMolecular Biology Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectClusterin-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectEye-
Palavras-chave: dc.subjectLacrimal film-
Palavras-chave: dc.subjectRetina-
Título: dc.titleThe protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2-
Aparece nas coleções:Repositório Institucional - Unesp

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