Gestational diabesity and foetoplacental vascular dysfunction

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.contributorUniversidad de Antofagasta-
Autor(es): dc.contributorUniversity Medical Center Groningen-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorPontificia Universidad Javeriana-
Autor(es): dc.contributorUniversidad del Bío-Bío-
Autor(es): dc.contributorUniversidad de Valparaíso-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.creatorCornejo, Marcelo-
Autor(es): dc.creatorFuentes, Gonzalo-
Autor(es): dc.creatorValero, Paola-
Autor(es): dc.creatorVega, Sofía [UNESP]-
Autor(es): dc.creatorGrismaldo, Adriana-
Autor(es): dc.creatorToledo, Fernando-
Autor(es): dc.creatorPardo, Fabián-
Autor(es): dc.creatorMoore-Carrasco, Rodrigo-
Autor(es): dc.creatorSubiabre, Mario-
Autor(es): dc.creatorCasanello, Paola-
Autor(es): dc.creatorFaas, Marijke M-
Autor(es): dc.creatorvan Goor, Harry-
Autor(es): dc.creatorSobrevia, Luis [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:47Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/apha.13671-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206327-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206327-
Descrição: dc.descriptionGestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D-glucose and other nutrients, thereby negatively affecting the foetoplacental vascular endothelium. Maternal hyperglycaemia and hyperinsulinemia play an important role in the aetiology of GDM. A combination of these and other factors predisposes women to developing GDM with pre-pregnancy normal weight, viz. classic GDM. However, women with GDM and prepregnancy obesity (gestational diabesity, GDty) or overweight (GDMow) show a different metabolic status than women with classic GDM. GDty and GDMow are associated with altered l-arginine/nitric oxide and insulin/adenosine axis signalling in the human foetoplacental microvascular and macrovascular endothelium. These alterations differ from those observed in classic GDM. Here, we have reviewed the consequences of GDty and GDMow in the modulation of foetoplacental endothelial cell function, highlighting studies describing the modulation of intracellular pH homeostasis and the potential implications of NO generation and adenosine signalling in GDty-associated foetal vascular insulin resistance. Moreover, with an increase in the rate of obesity in women of childbearing age worldwide, the prevalence of GDty is expected to increase in the next decades. Therefore, we emphasize that women with GDty and GDMow should be characterized with a different metabolic state from that of women with classic GDM to develop a more specific therapeutic approach for protecting the mother and foetus.-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Talca-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Antofagasta-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Nutrition and Biochemistry Faculty of Sciences Pontificia Universidad Javeriana-
Descrição: dc.descriptionDepartment of Basic Sciences Faculty of Sciences Universidad del Bío-Bío-
Descrição: dc.descriptionMetabolic Diseases Research Laboratory Interdisciplinary Centre of Territorial Health Research (CIISTe) Biomedical Research Center (CIB) School of Medicine Faculty of Medicine Universidad de Valparaíso-
Descrição: dc.descriptionDepartment of Obstetrics Division of Obstetrics and Gynaecology and Department of Neonatology Division of Pediatrics School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationActa Physiologica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadenosine-
Palavras-chave: dc.subjectdiabesity-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectintracellular pH-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectplacenta-
Título: dc.titleGestational diabesity and foetoplacental vascular dysfunction-
Aparece nas coleções:Repositório Institucional - Unesp

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