Analgesic effects of a 5% lidocaine patch after cesarean section: A randomized placebo-controlled double-blind clinical trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCampina Grande Federal University Rua Aprigio Veloso-
Autor(es): dc.creatorde Queiroz, Vaniely Kaliny Pinheiro [UNESP]-
Autor(es): dc.creatorda Nóbrega Marinho, Alexandre Magno-
Autor(es): dc.creatorde Barros, Guilherme Antonio Moreira [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:44Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jclinane.2021.110328-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206310-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206310-
Descrição: dc.descriptionStudy objective: This study aimed to evaluate the analgesic effects of a 5% lidocaine patch in acute postoperative pain after cesarean section. Design: This is a prospective, randomized, double-blind study. Setting: After surgery, active and placebo patches were applied in the operating room, and patients were evaluated during their stay at the postoperative recovery room and at the hospital ward. Patients: Seventy-two women (18 years of age or older and American Society of Anesthesiologists status II) scheduled for cesarean section under spinal anesthesia were enrolled in the study. Interventions: Patients were randomly assigned to an intervention or placebo group. According to the assigned group, a 5% lidocaine patch or a placebo patch was applied 1 cm above and below the Pfannenstiel incision after the surgery. Measurements: The primary outcome was the pain score, evaluated using an 11-point numerical verbal scale in the first 36 h postoperatively. Secondary outcomes were the quality of recovery 24 h after surgery, consumption of rescue opioids, and the presence of adverse effects. Main results: Sixty-five women completed the study. The pain score was lower in the lidocaine group at 6 h (lidocaine group: 2.16 ± 1.71, placebo group: 3.21 ± 2.25; p = 0.031), 12 h (lidocaine: 1.58 ± 0.81, placebo: 2.24 ± 0.74; p = 0.001), 24 h (lidocaine: 0.74 ± 0.89, placebo: 1.94 ± 1.39; p < 0.0001), and 36 h (lidocaine: 0.48 ± 1.03, placebo: 1.68 ± 0.94; p = 0.001) after surgery. There were no differences in secondary outcomes during the follow-up period. Conclusion: The lidocaine patch reduced pain scores compared to placebo in the first 36 h after the surgery, despite no influence over opioid consumption, quality of recovery, or incidence of side effects.-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n 18618687-
Descrição: dc.descriptionMedical School Campina Grande Federal University Rua Aprigio Veloso-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n 18618687-
Idioma: dc.languageen-
Relação: dc.relationJournal of Clinical Anesthesia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute pain-
Palavras-chave: dc.subjectCesarean section-
Palavras-chave: dc.subjectEnhanced postsurgical recovery-
Palavras-chave: dc.subjectLidocaine-
Palavras-chave: dc.subjectTransdermal patch-
Título: dc.titleAnalgesic effects of a 5% lidocaine patch after cesarean section: A randomized placebo-controlled double-blind clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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