Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBarssotti, Leticia-
Autor(es): dc.creatorAbreu, Isabel C. M. E.-
Autor(es): dc.creatorBrandão, Ana Beatriz P.-
Autor(es): dc.creatorAlbuquerque, Raquel C. M. F.-
Autor(es): dc.creatorFerreira, Fabiana G.-
Autor(es): dc.creatorSalgado, Miguel A. C. [UNESP]-
Autor(es): dc.creatorDias, Danielle D. S.-
Autor(es): dc.creatorDe Angelis, Kátia-
Autor(es): dc.creatorYokota, Rodrigo-
Autor(es): dc.creatorCasarini, Dulce E.-
Autor(es): dc.creatorSouza, Lívia B.-
Autor(es): dc.creatorTaddei, Carla R.-
Autor(es): dc.creatorCunha, Tatiana S.-
Data de aceite: dc.date.accessioned2022-02-22T00:46:36Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:36Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-88497-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206266-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206266-
Descrição: dc.descriptionType 1 diabetes (T1DM) is a chronic disease characterized by hyperglycemia due to a deficiency in endogenous insulin production, resulting from pancreatic beta cell death. Persistent hyperglycemia leads to enhanced oxidative stress and liver injury. Several studies have evaluated the anti-diabetic and protective effects of probiotic strains in animal models. In the present study, we investigated, through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii (S. boulardii) yeast on the liver of streptozotocin (STZ) induced diabetic C57BL/6 mice. Our results demonstrated that S. boulardii attenuates hepatocytes hydropic degeneration and hepatic vessels congestion in STZ-induced diabetic mice. The treatment attenuated the oxidative stress in diabetic mice leading to a reduction of carbonylated protein concentration and increased activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase, compared to untreated diabetic animals. The results also show the beneficial influence of S. boulardii in regulating the hepatic concentration of renin angiotensin system (RAS) peptides. Therefore, our results demonstrated that S. boulardii administration to STZ-induced diabetic mice reduces oxidative stress and normalizes the concentration of RAS peptides, supporting the hypothesis that this yeast may have a role as a potential adjunctive therapy to attenuate diabetes-induced liver injury.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Science and Technology Federal University of São Paulo (Unifesp)-
Descrição: dc.descriptionDepartment of Medicine Federal University of São Paulo (Unifesp)-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis State University Julio de Mesquita Filho (Unesp)-
Descrição: dc.descriptionDepartment of Physiology Federal University of São Paulo (Unifesp)-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses University of São Paulo (Usp)-
Descrição: dc.descriptionFederal University of São Paulo (Unifesp) - Institute of Science and Technology, Talim, 330 – Vila Nair-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis State University Julio de Mesquita Filho (Unesp)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2016/24059-2-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleSaccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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