Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInstituto Conmemorativo Gorgas de Estudios de la Salud-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidad Nacional Autónoma de Honduras-
Autor(es): dc.contributorHospital Escuela-
Autor(es): dc.contributorUniversidad de Panamá-
Autor(es): dc.contributorInstituto Evandro Chagas-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.creatorSandoval Pacheco, Carmen M.-
Autor(es): dc.creatorAraujo Flores, Gabriela V.-
Autor(es): dc.creatorGonzalez, Kadir-
Autor(es): dc.creatorDe Castro Gomes, Claudia M.-
Autor(es): dc.creatorPassero, Luiz F. D. [UNESP]-
Autor(es): dc.creatorTomokane, Thaise Y.-
Autor(es): dc.creatorSosa-Ochoa, Wilfredo-
Autor(es): dc.creatorZúniga, Concepción-
Autor(es): dc.creatorCalzada, Jose-
Autor(es): dc.creatorSaldaña, Azael-
Autor(es): dc.creatorCorbett, Carlos E. P.-
Autor(es): dc.creatorSilveira, Fernando T.-
Autor(es): dc.creatorLaurenti, Marcia D.-
Data de aceite: dc.date.accessioned2022-02-22T00:46:36Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:36Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2021/5596876-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206262-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206262-
Descrição: dc.descriptionMacrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1=112±12, M2=43±12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1=195±25, M2=616±114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1=97±24, M2=219±29), L. (V.) panamensis (M1=71±14, M2=164±14), and L. (V.) braziliensis (M1=50±13, M2=53±10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.-
Descrição: dc.descriptionDepartamento de Patologia Laboratório de Patologia de Moléstias Infecciosas Faculdade de Medicina Universidade de São Paulo, Av. Doutor Arnaldo 455-
Descrição: dc.descriptionDepartamento de Parasitología Molecular Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Institute for Advanced Studies of Ocean-
Descrição: dc.descriptionInstituto de Investigación en Microbiología Universidad Nacional Autónoma de Honduras-
Descrição: dc.descriptionDepartamento de Vigilancia de la Salud Hospital Escuela-
Descrição: dc.descriptionFacultad de Medicina Veterinaria Universidad de Panamá Campus Harmodio Arias Madrid, Av. Juan Pablo II-
Descrição: dc.descriptionCentro de Investigación y Diagnóstico de Enfermedades Parasitarias Facultad de Medicina Universidad de Panamá, Ave. Octavio Méndez Pereira-
Descrição: dc.descriptionDepartamento de Parasitologia Instituto Evandro Chagas-
Descrição: dc.descriptionNúcleo de Medicina Tropical Universidade Federal de Pará-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Institute for Advanced Studies of Ocean-
Idioma: dc.languageen-
Relação: dc.relationJournal of Immunology Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleMacrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp-
Tipo de arquivo: dc.typelivro digital-
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