Synbiotic sheep milk ice cream reduces chemically induced mouse colon carcinogenesis

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFederal Fluminense University (UFF)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal Institute of Rio de Janeiro (IFRJ)-
Autor(es): dc.contributorFederal Institute of Paraná (IFPR)-
Autor(es): dc.contributorRural Federal University of Rio de Janeiro (UFRRJ)-
Autor(es): dc.contributorUniversity of Foggia (UNIFG)-
Autor(es): dc.creatorBalthazar, Celso F.-
Autor(es): dc.creatorde Moura, Nelci A. [UNESP]-
Autor(es): dc.creatorRomualdo, Guilherme R. [UNESP]-
Autor(es): dc.creatorRocha, Ramon S.-
Autor(es): dc.creatorPimentel, Tatiana C.-
Autor(es): dc.creatorEsmerino, Erick A.-
Autor(es): dc.creatorFreitas, Mônica Q.-
Autor(es): dc.creatorSantillo, Antonella-
Autor(es): dc.creatorSilva, Marcia Cristina-
Autor(es): dc.creatorBarbisan, Luis F.-
Autor(es): dc.creatorCruz, Adriano G.-
Autor(es): dc.creatorAlbenzio, Marzia-
Data de aceite: dc.date.accessioned2022-02-22T00:46:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:35Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3168/jds.2020-19979-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206257-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206257-
Descrição: dc.descriptionSheep dairy products containing prebiotic and probiotic ingredients may have health-promoting properties. Thus, this study evaluated the effects of sheep milk ice cream [conventional full-fat (CONV), full-fat enriched with probiotic (PROB, 100 mg % wt/wt of Lacticaseibacillus casei 01), or nonfat synbiotic (SYNB, Lacticaseibacillus casei 01 and inulin, 10% wt/wt)] on carcinogen-induced colonic crypt cytotoxicity and premalignant lesion development. Male Swiss mice received 2 doses of colon carcinogen azoxymethane (AOM, 15 mg/kg of body weight) at wk 3 and 4. Two weeks before and during AOM administrations (4 wk) mice were treated with CONV, PROB, or SYNB by gavage (10 mL/kg). Mice were euthanized at wk 4 or 25 (n = 5 or 10 mice/group, respectively). At wk 4, a significant reduction in micronucleated colonocytes was observed in PROB and SYNB groups, and a significant decrease in both p53 expression and apoptosis indexes in colonic crypts was observed in SYNB group. At wk 25, both PROB and SYNB interventions reduced the mean number of colonic premalignant lesions. However, only SYNB group showed lower incidence and number of high-grade premalignant lesions in the colonic mucosa. These findings indicate that PROB or SYNB sheep milk ice cream, especially SYNB intervention, can reduce chemically induced mouse colon carcinogenesis.-
Descrição: dc.descriptionDepartment of Food Science and Nutrition Faculty of Food Engineering University of Campinas-
Descrição: dc.descriptionDepartment of Veterinary Hygiene and Technological Processing of Animal Products Veterinary School Federal Fluminense University (UFF)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Food Federal Institute of Rio de Janeiro (IFRJ)-
Descrição: dc.descriptionDepartment of Food Science Federal Institute of Paraná (IFPR), Paranavaí-
Descrição: dc.descriptionDepartment of Food Technology Rural Federal University of Rio de Janeiro (UFRRJ)-
Descrição: dc.descriptionDepartment of Agriculture Food Natural Resources and Engineering (DAFNE) University of Foggia (UNIFG)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dairy Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectazoxymethane-
Palavras-chave: dc.subjectcolon carcinogenesis-
Palavras-chave: dc.subjectsheep dairy food-
Palavras-chave: dc.subjectsynbiotic-
Título: dc.titleSynbiotic sheep milk ice cream reduces chemically induced mouse colon carcinogenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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