Single nucleotide polymorphisms affect miRNA target prediction in bovine

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity ofQueensland-
Autor(es): dc.creatorde Sousa, Marco Antônio Perpétuo [UNESP]-
Autor(es): dc.creatorde Athayde, Flavia Regina Florêncio [UNESP]-
Autor(es): dc.creatorMaldonado, Mariângela Bueno Cordeiro [UNESP]-
Autor(es): dc.creatorde Lima, Andressa Oliveira [UNESP]-
Autor(es): dc.creatorFortes, Marina Rufino S.-
Autor(es): dc.creatorLopes, Flavia Lombardi [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:30Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0249406-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206225-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206225-
Descrição: dc.descriptionSingle nucleotide polymorphisms (SNPs) can have significant effects on phenotypic characteristics in cattle. MicroRNAs (miRNAs) are small, non-coding RNAs that act as post-transcriptional regulators by binding them to target mRNAs. In the present study, we scanned ~56 million SNPs against 1,064 bovine miRNA sequences and analyzed, in silico, their possible effects on target binding prediction, primary miRNA formation, association with QTL regions and the evolutionary conservation for each SNP locus. Following target prediction, we show that 71.6% of miRNA predicted targets were altered as a consequence of SNPs located within the seed region of the mature miRNAs. Next, we identified variations in the Minimum Free Energy (MFE), which represents the capacity to alter molecule stability and, consequently, miRNA maturation. A total of 48.6% of the sequences analyzed showed values within those previously reported as sufficient to alter miRNA maturation. We have also found 131 SNPs in 46 miRNAs, with altered target prediction, occurring in QTL regions. Lastly, analysis of evolutionary conservation scores for each SNP locus suggested that they have a conserved biological function through the evolutionary process. Our results suggest that SNPs in microRNAs have the potential to affect bovine phenotypes and could be of great value for genetic improvement studies, as well as production.-
Descrição: dc.descriptionDepartment of Production and Animal Health São Paulo State University (Unesp) School of VeterinaryMedicine-
Descrição: dc.descriptionSchool of Chemistry and Molecular Bioscience University ofQueensland-
Descrição: dc.descriptionDepartment of Production and Animal Health São Paulo State University (Unesp) School of VeterinaryMedicine-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleSingle nucleotide polymorphisms affect miRNA target prediction in bovine-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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